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Updated: 3 days 12 hours ago

Erratum for the Research Article “Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy” by W. Lu et al. | Science Translational Medicine

Wed, 27/11/2024 - 16:01
Data file S1 of the Research Article “Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy” by W. Lu et al. was missing the data for Fig. 1C. These data have now been added to data file S1, and the other data and the conclusions are not affected.
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Erratum for the Research Article “Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma” by S. Islam et al. | Science Translational Medicine

Wed, 27/11/2024 - 16:01
The Funding section of the Research Article “Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma” by S. Islam et al. has been updated to include support for author Sahana Lothumalla from a CPRIT Research Training Award, CPRIT Training Program (RP210028).
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Seeding-competent TDP-43 persists in human patient and mouse muscle | Science Translational Medicine

Wed, 27/11/2024 - 16:01
TDP-43 aggregate seeds persist in mouse and human skeletal muscle independent of large TDP-43 inclusions.
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A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models | Science Translational Medicine

Wed, 27/11/2024 - 16:01
A wearable osmotic microneedle patch with high loading capacity provides sustained drug delivery for 24 hours in small- and large-animal models.
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Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells | Science Translational Medicine

Wed, 27/11/2024 - 16:01
Kidney stroma and immune cells interact during inflammation in childhood-onset lupus nephritis.
Categories: Science

Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans | Science Translational Medicine

Wed, 27/11/2024 - 16:01
A study of the role of angiogenesis in the human brain aging uncovers sex-specific associations with structural and functional brain outcomes.
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Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation | Science Translational Medicine

Wed, 27/11/2024 - 16:01
cAMP metabolic reprogramming triggers AMPK-dependent autophagy, promoting liver injury during long-term supercooling.
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An mRNA-encoded dominant-negative inhibitor of transcription factor RUNX1 suppresses vitreoretinal disease in experimental models | Science Translational Medicine

Wed, 27/11/2024 - 16:01
An mRNA-encoded, dominant-negative inhibitor of RUNX1 exhibits preclinical efficacy in models of ocular diseases.
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Erratum for the Research Article “Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice” by S. Gaikwad et al. | Science Translational Medicine

Wed, 20/11/2024 - 16:01
In the Research Article “Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice” by S. Gaikwad et al., an unintentional error was made in Fig. 3E where the synaptophysin bands were duplicated for NeuN bands. The correct NeuN bands have been incorporated in Fig. 3E along with their quantification in Fig. 3H. In the Results section, the text “Consistent with these findings, compared with IgG-ms–treated hTau mice, TTCM2-ms–treated hTau mice showed increased protein levels of neuronal markers, including PSD95, and synaptophysin, and neuronal nuclear protein (NeuN) in the hippocampus—the region associated with memory formation and cognitive functions (Fig. 3, E to H). Immunofluorescence microscopy also showed an increase in the number of NeuN-positive cells in the hippocampi of TTCM2-ms–treated hTau mice (fig. S2, A and B)” was corrected to “Compared with IgG-ms–treated hTau mice, TTCM2-ms–treated hTau mice showed a nonsignificant (PSD95, P = 0.0591) and significant (synaptophysin, P = 0.0054) increase in protein abundance of synaptic markers in the hippocampus—the region associated with memory formation and cognitive functions (Fig. 3, E to G). Neuronal nuclear protein (NeuN, P = 0.3026) protein was not increased (Fig. 3, E and H), but immunofluorescence microscopy showed an increase in the number of NeuN-positive cells in the hippocampi of TTCM2-ms–treated hTau mice (fig. S2, A and B).” The online PDF and HTML (full text) have been updated. These corrections do not affect the overall conclusions of the paper.
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Erratum for the Research Article “An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease” by A. Ghosh et al. | Science Translational Medicine

Wed, 20/11/2024 - 16:01
In the Research Article “An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease” by A. Ghosh et al., there was a duplication error in Fig. 5C. The N-Tg TPPU images were the same as the N-Tg Veh images. The correct N-Tg TPPU images are now in Fig. 5C, and the conclusions and other data in the paper are not affected.
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Delayed low-dose oral administration of 4′-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease | Science Translational Medicine

Wed, 20/11/2024 - 16:01
Low-dose oral ribonucleoside analog is efficacious in guinea pig models of lethal arenavirus disease when administered before and during peak fever.
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Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis | Science Translational Medicine

Wed, 20/11/2024 - 16:01
CDK7 inhibitors reverse inflammatory macrophage phenotypes and show therapeutic promise in rheumatoid arthritis models and patient synovial cells.
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Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine

Wed, 20/11/2024 - 16:01
Genipin rescues developmental and degenerative phenotypes of the peripheral neuropathy familial dysautonomia and enhances neuron regeneration.
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NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer | Science Translational Medicine

Wed, 20/11/2024 - 16:01
Degradation or depletion of NIT2 drives chemoresistance in gastric cancer by promoting H3K14ac-mediated oxidative phosphorylation.
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Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells | Science Translational Medicine

Wed, 20/11/2024 - 16:01
Blocking Roundabout signaling combats ocular neovascularization by preventing macrophage activation.
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Vagal stimulation ameliorates murine colitis by regulating SUMOylation | Science Translational Medicine

Wed, 20/11/2024 - 16:01
Vagal stimulation or inhibition of SUMOylation with TAK-981 ameliorates colitis in mouse models.
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Initiating Long Covid RECOVERy | Science Translational Medicine

Wed, 13/11/2024 - 16:01
The NIH’s RECOVER Initiative aims to ease the suffering of those living with Long Covid.
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Symptoms after Lyme disease: What’s past is prologue | Science Translational Medicine

Wed, 13/11/2024 - 16:01
Diverse mechanisms contribute to persistent symptoms after Lyme disease, and a holistic multidisciplinary approach is needed to optimize care.
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Sex differences in postacute infection syndromes | Science Translational Medicine

Wed, 13/11/2024 - 16:01
Understanding postacute infection syndromes requires sex-specific research approaches.
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Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler’s web | Science Translational Medicine

Wed, 13/11/2024 - 16:01
A research agenda that studies Long Covid in the context of related conditions could transform our understanding of these disabling illnesses.
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