Science Translational Medicine weekly highlights

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Science Translational Medicine: At the intersection of science, engineering and medicine.
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Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes | Science Translational Medicine

Wed, 22/05/2024 - 16:01
A whole blood DNA methylation signature can improve prediction of kidney failure risk in type 1 diabetes.
Categories: Science

Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell–engaging bispecific antibody targeting human claudin 6 | Science Translational Medicine

Wed, 22/05/2024 - 16:01
The anti-CLDN6 T cell engager RiboMab02.1 encoded by BNT142 RNA-LNP shows favorable preclinical pharmacology against CLDN6-positive solid tumors.
Categories: Science

Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice | Science Translational Medicine

Wed, 22/05/2024 - 16:01
TRPV4-mediated BSCB breakdown is a reversible driver of motor neuron degeneration in mice.
Categories: Science

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses | Science Translational Medicine

Wed, 22/05/2024 - 16:01
The small-molecule GS-5245 is therapeutically efficacious in animals infected with different pandemic, epidemic, or enzootic coronaviruses.
Categories: Science

Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice | Science Translational Medicine

Thu, 16/05/2024 - 16:01
An HIV vaccine first-boost candidate immunogen promoted maturation of VRC01-class antibodies in a humanized mouse model, supporting clinical testing.
Categories: Science

Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis | Science Translational Medicine

Wed, 15/05/2024 - 16:01
Tumor-associated NK cells induce myeloid-derived suppressor cells to suppress antitumor T cell responses.
Categories: Science

Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays | Science Translational Medicine

Wed, 15/05/2024 - 16:01
SARS-CoV-2 neutralization titers are consistent across different assays and across human and animal model serum when considering four criteria.
Categories: Science

Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients | Science Translational Medicine

Wed, 15/05/2024 - 16:01
The frequency of essential tremor is encoded by the population tuning of neuronal activity in the olivocerebellum, leading to coherent circuitry oscillations.
Categories: Science

Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe | Science Translational Medicine

Wed, 15/05/2024 - 16:01
Neuro optical coherence tomography provided high-resolution, volumetric intravascular imaging for cerebrovascular circulation and neurointervention.
Categories: Science

SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma | Science Translational Medicine

Wed, 15/05/2024 - 16:01
SRC controls S6K/S6 and translation through a suppressive MAGI1-PP2A complex, creating a targetable dependency in IDH-mutant cholangiocarcinoma.
Categories: Science

Erratum for the Research Article “Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma” by S. Manier et al. | Science Translational Medicine

Wed, 08/05/2024 - 16:01
HomeScience Translational MedicineVol. 16, No. 746Erratum for the Research Article “Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma” by S. Manier et al.Back To Vol. 16, No. 746 Full accessErrata Share on Erratum for the Research Article “Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma” by S…
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Erratum for the Research Article “A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer” by A. M. Miller et al. | Science Translational Medicine

Wed, 08/05/2024 - 16:01
HomeScience Translational MedicineVol. 16, No. 746Erratum for the Research Article “A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer” by A. M. Miller et al.Back To Vol. 16, No. 746 Full accessErrata Share on Erratum for the Research Article “A functional identification platform reveals frequent, spontaneous neoantigen-…
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The translational gap for gene therapies in low- and middle-income countries | Science Translational Medicine

Wed, 08/05/2024 - 16:01
Local capacity should be prioritized for gene therapies that combat diseases prevalent in low- and middle-income countries.
Categories: Science

A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes | Science Translational Medicine

Wed, 08/05/2024 - 16:01
Single-dose expanded Tregs do not preserve clinical β cell function in new-onset T1D, despite their in vitro efficacy.
Categories: Science

MRGPRX4 mediates phospho-drug–associated pruritus in a humanized mouse model | Science Translational Medicine

Wed, 08/05/2024 - 16:01
Phosphate modification of medications triggers pruritus through the sensory neuron receptor MRGPRX4.
Categories: Science

Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function | Science Translational Medicine

Wed, 08/05/2024 - 16:01
Iron regulates the metabolism and effector functions of ILC2s in murine and humanized models of ILC2-dependent allergic asthma.
Categories: Science

Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects | Science Translational Medicine

Wed, 08/05/2024 - 16:01
A human aortic aneurysm model using bioengineered vascular grafts reveals insights into the pathogenesis of Loeys-Dietz syndrome.
Categories: Science

Nothing about us without us: Advocacy and engagement in genetic medicine | Science Translational Medicine

Wed, 08/05/2024 - 16:01
New genetic medicines for sickle cell disease highlight the need for greater community advocacy to ensure access for all.
Categories: Science

Erratum for the Research Article “Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit” by D. J. Schwartz et al. | Science Translational Medicine

Wed, 01/05/2024 - 16:01
HomeScience Translational MedicineVol. 16, No. 745Erratum for the Research Article “Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit” by D. J. Schwartz et al.Back To Vol. 16, No. 745 Full accessErrata Share on Erratum for the Research Article “Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit” by D. J. Schwartz…
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Vaccination for healthy aging | Science Translational Medicine

Wed, 01/05/2024 - 16:01
Vaccination as a strategy to promote healthy aging is associated with challenges, opportunities, and implications for policy.
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