Science Translational Medicine weekly highlights


Science Translational Medicine: At the intersection of science, engineering and medicine.
Updated: 3 days 16 hours ago
Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth | Science Translational Medicine
Mouse models of papillary craniopharyngioma enable drug screening and reveal that hypothalamic neurons drive tumor growth through synaptic contact.
Categories: Science
Erratum for the Review “Engineering CAR-T therapies for autoimmune disease and beyond” by E. P. English et al. | Science Translational Medicine
In Table 1 of the Review “Engineering CAR-T therapies for autoimmune disease and beyond” by E. P. English et al., the sponsors of the clinical trials in the last section, “Engineered cell therapy studies in autoimmune diseases (non-BCMA or -CD19 targets),” were incorrect. The clinical trials and sponsors were originally listed as follows: NCT03605238, NCT05239702, and NCT06361836, Cabaletta Bio; NCT04422912, Tongji Hospital; NCT04561557, Zhejiang University; NCT05451212, Nanjing University School of Medicine; NCT06285279, Luminary Therapeutics; NCT06340750, 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China; and NCT06352281, Sonoma Biotherapeutics, Inc. The clinical trials and sponsors are now correctly assigned as follows: NCT03605238, Chinese PLA General Hospital; NCT04422912 and NCT05451212, Cabaletta Bio; NCT04561557, Tongji Hospital; NCT05239702, Zhejiang University; NCT06285279, Nanjing University School of Medicine; NCT06340750, Luminary Therapeutics; NCT06352281, 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China; and NCT06361836, Sonoma Biotherapeutics, Inc.
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Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation | Science Translational Medicine
Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation and suppresses skin inflammation.
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ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes | Science Translational Medicine
ATP citrate lyase is a target for therapeutic interventions in pulmonary hypertension and coronary artery disease.
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Development of a fibrin-targeted theranostic for gastric cancer | Science Translational Medicine
Fibrin within the tumor can be used as a target for the detection and treatment of gastric cancer.
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Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity | Science Translational Medicine
Sensitization of the keratinocyte mechanotransducer PIEZO1 contributes to paclitaxel-induced touch pain.
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ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools | Science Translational Medicine
This study uncovers a pathway controlling fatty acid distribution in adipose tissue macrophages and insulin resistance in obesity.
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Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation | Science Translational Medicine
Computational and molecular analysis identified benzamil as a potential treatment for skin inflammation in murine and human xenograft skin models.
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Predicting the next round of drugs for Medicare price negotiation | Science Translational Medicine
Uncertainty remains regarding which brand-name prescription drugs will have their prices negotiated by Medicare in 2025.
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Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation | Science Translational Medicine
Diverse natural killer T cells regulate innate immunity to improve neurological outcomes and survival after cardiac arrest.
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RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice | Science Translational Medicine
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
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Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease | Science Translational Medicine
Loss of NPC1 in microglia increases TSPO and triggers astrogliosis and neurodegeneration.
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Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment | Science Translational Medicine
Single-cell immune profiling of tumor-infiltrating T lymphocytes in acral melanoma revealed increased NKG2A expression in antitumor TILs.
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Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist | Science Translational Medicine
Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.
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Erratum for the Research Article “Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy” by W. Lu et al. | Science Translational Medicine
Data file S1 of the Research Article “Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy” by W. Lu et al. was missing the data for Fig. 1C. These data have now been added to data file S1, and the other data and the conclusions are not affected.
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Erratum for the Research Article “Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma” by S. Islam et al. | Science Translational Medicine
The Funding section of the Research Article “Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma” by S. Islam et al. has been updated to include support for author Sahana Lothumalla from a CPRIT Research Training Award, CPRIT Training Program (RP210028).
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Seeding-competent TDP-43 persists in human patient and mouse muscle | Science Translational Medicine
TDP-43 aggregate seeds persist in mouse and human skeletal muscle independent of large TDP-43 inclusions.
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A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models | Science Translational Medicine
A wearable osmotic microneedle patch with high loading capacity provides sustained drug delivery for 24 hours in small- and large-animal models.
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Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells | Science Translational Medicine
Kidney stroma and immune cells interact during inflammation in childhood-onset lupus nephritis.
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Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans | Science Translational Medicine
A study of the role of angiogenesis in the human brain aging uncovers sex-specific associations with structural and functional brain outcomes.
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