Sally N Adebamowo https://datingranking.net/straight-dating/, Donna Spiegelman, Walter C Willett, Kathryn M Rexrode, Association ranging from intakes regarding magnesium, potassium, and you can calcium and you will threat of coronary attack: 2 cohorts folks girls and you may upgraded meta-analyses, The latest Western Log of Systematic Nourishment, Regularity 101, Point six, , Pages 1269–1277,
Abstract
Background: Potential analysis into the relation from magnesium, potassium, and calcium intakes with stroke chance is contradictory, also to our studies, the effect out-of a combined mineral diet get wasn’t tested.
Objective: I checked out associations ranging from consumption regarding magnesium, potassium, and you will calcium and you can threat of experience coronary attack when you look at the 86,149 women in the fresh Nurses’ Fitness Studies (NHS) We and you can 94,715 ladies in the new NHS II.
Design: Contained in this potential cohort research, i determined Hours regarding heart attack of the quintiles out of intake each nutrient and for a mixed diet score of all 3 nutritional elements that with multivariate Cox proportional issues patterns. In addition, we upgraded meta-analyses to your fat reduction consumption of these nutrition and likelihood of coronary attack.
Results: Throughout the pursue-upwards (29 y from the NHS We; twenty-two y in the NHS II) a total of 3780 incident coronary attack cases were noted. Pooled multivariate RRs from full stroke for ladies in the large weighed against a reduced quintiles was indeed 0.87 (95% CI: 0.78, 0.97) to own full magnesium, 0.89 (95% CI: 0.80, 0.99) to own complete potassium, and you can 0.97 (95% CI: 0.87, step one.09) to own complete calcium consumption. Pooled RRs for women about high weighed against a decreased quintiles away from a mixed mineral diet rating was in fact 0.72 (95% CI: 0.65, 0.81) getting total coronary arrest, 0.78 (95% CI: 0.66, 0.92) to possess ischemic stroke, and you can 0.80 (95% CI: 0.61, 1.04) getting hemorrhagic coronary arrest. From the upgraded meta-analyses of all the potential education up until now, this new mutual RR from complete coronary arrest try 0.87 (95% CI: 0.83, 0.92) for a 100-mg/d upsurge in magnesium intake, 0.91 (95% CI: 0.88, 0.94) to have a beneficial 1000-mg/d increase in potassium consumption, and you can 0.98 (95% CI: 0.94, step one.02) to possess a three hundred-mg/d boost in calcium supplements consumption.
Conclusions: A blended nutrient diet rating was inversely regarding the chance of stroke. Highest consumption off magnesium and potassium however calcium were together with significantly associated with the faster threat of coronary arrest in women.
Inclusion
Magnesium is an essential mineral and cofactor getting >three hundred enzymatic reactions in the torso ( 1). Magnesium ‘s the 2nd really-numerous intracellular cation alongside potassium ( 2). Calcium is one of-abundant nutrient in the human body. Eg magnesium and you may potassium, calcium is critically in cardio characteristics ( 3). High dietary consumption of any of those nutrients was indeed claimed to help you down threat of blood pressure ( 4– 7), the prominent modifiable coronary arrest exposure basis. Yet not, not totally all potential degree checked out the latest loved ones anywhere between weight-loss and you will supplemental intakes of those nutrients and you will danger of heart attack in women, and you will efficiency was in fact inconsistent. Prospective training from inside the Europe presented magnesium consumption, not intake off potassium or calcium, is rather regarding the reduced danger of coronary arrest ( eight, 8). In the united states, consumption off potassium and you may magnesium, but not away from calcium, was from the smaller coronary attack chance in people ( 9), whereas calcium and potassium consumption, not magnesium consumption, was in fact for the smaller heart attack chance in females ( 10). Also, that analysis showed zero complete organization anywhere between any of these nutrients and you may danger of heart attack ( 11).
The prospective observational knowledge that have been presented don’t tend to be follow-upwards past fifteen y and had a somewhat few event heart attack incidents, plus in really knowledge, the new independent aftereffect of for each and every nutrient consumption away from products and you can stroke versions wasn’t looked at. On this page, you can expect proof on organization of each and every nutrient intake away from diet and medications that have threat of total, ischemic, and you will hemorrhagic event strokes. Simultaneously, i hypothesized one a mixed diet get of all the step three nutritional elements can be of this shorter heart attack risk because these nutrition can be found with her from inside the items, and you will consumption are highly coordinated. We managed such seeks within the All of us women that was accompanied prospectively from the dos large cohorts new Nurses’ Health Studies (NHS) 5 I and you will II.