From a particle smasher encircling the moon to an “impossible” laser, five scientists reveal the experiments they would run in a world powered purely by imagination

From a particle smasher encircling the moon to an “impossible” laser, five scientists reveal the experiments they would run in a world powered purely by imagination

The rollout of a type of genetic technology called a gene drive for tackling malaria could be edging closer after a lab study supports its success

The rollout of a type of genetic technology called a gene drive for tackling malaria could be edging closer after a lab study supports its success

An excavation in Suffolk, UK, has uncovered pyrite and flint that appear to have been used by ancient humans to light fires some 400,000 years ago

An excavation in Suffolk, UK, has uncovered pyrite and flint that appear to have been used by ancient humans to light fires some 400,000 years ago

In the Research Article “Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis” by Z. Zhang et al., there were inadvertent image duplications in Figs. 4F, 6F, and S7. In Fig. 4F, the Lgr5 smFISH staining of 3-week wild-type and Ednrb−/− mouse colon was inadvertently duplicated from the 2-week group shown in Fig. 3H. In Fig. 6F, the 40× image for HSCR colostomy rectum stained for PDGFRα/MMP1/DAPI did not match the corresponding 10× image. In fig. S7, the image representing HSCR-derived organoids on day 0 was incorrect and duplicated from the images shown in Fig. 7J. Figures 4F and 6F and fig. S7 have been updated with the correct images. The other data and the conclusions in the paper are not affected.

Antigen-agnostic isolation of B cells enabled the AI-assisted identification of broadly neutralizing antibodies targeting OPG153.

ZAP327 CAR T cells outperform conventional CAR T cells in antitumor efficacy and safety by increasing the memory cell population.

Alternative splicing resulting in STAT3 that lacks a single amino acid, S701, increases colonic inflammation and tumorigenesis.

Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.

Clinical phenotypes are modestly associated with distinct channel dysfunctions caused by 42 CACNA1A de novo variants.

Preclinical models of SARS-CoV-2 vaccination revealed a targetable CXCL10–IFN-γ axis that drives cytokine-induced cardiac injury.

A mineralized collagen scaffold activates Gli1 expression and supports fibrocartilage repair in preclinical enthesis injury.

From bonobos and rats to tickling robots, research is finally cracking the secrets of why we’re ticklish, and what that reveals about our brains

From bonobos and rats to tickling robots, research is finally cracking the secrets of why we’re ticklish, and what that reveals about our brains

As Australian teenagers lose access to social media, observers say there are still many unknown questions about the ban, which came into force on 10 December

As Australian teenagers lose access to social media, observers say there are still many unknown questions about the ban, which came into force on 10 December

For centuries, Europeans thought that eternal daylight saturated the cosmos. The shift to a dark universe has had a profound psychological impact upon us

For centuries, Europeans thought that eternal daylight saturated the cosmos. The shift to a dark universe has had a profound psychological impact upon us