Science
EGFR inhibition down-regulates MGMT and enhances responsiveness to temozolomide in glioblastoma | Science Translational Medicine
Inhibiting EGFR before treatment with temozolomide enhances its efficacy in experimental models of glioblastoma.
Categories: Science
Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia | Science Translational Medicine
Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.
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Targeting of CH25H to boost p62-dependent autophagic degradation of α-synuclein in cell and mouse models of Parkinson’s disease | Science Translational Medicine
Competitive binding of cholesterol 25-hydroxylase with p62 inhibits autophagic degradation of α-synuclein.
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Why Schrödinger's 1944 classic What Is Life? still feels prescient
Pioneer of quantum mechanics Erwin Schrödinger's look at living organisms is one of the most influential popular-science books of the 20th century. So how does it hold up today, asks Karmela Padavic-Callaghan
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Why Schrödinger's 1944 classic What Is Life? still feels prescient
Pioneer of quantum mechanics Erwin Schrödinger's look at living organisms is one of the most influential popular-science books of the 20th century. So how does it hold up today, asks Karmela Padavic-Callaghan
Categories: Science
Lambs born via IVF using highly immature eggs in major breakthrough
Lambs have been born using an experimental form of IVF that coaxes immature eggs to become mature ones. This could boost the number of eggs available for fertilisation and improve IVF success rates
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Lambs born via IVF using highly immature eggs in major breakthrough
Lambs have been born using an experimental form of IVF that coaxes immature eggs to become mature ones. This could boost the number of eggs available for fertilisation and improve IVF success rates
Categories: Science
The allergy culprit histamine also boosts our memory
A drug that raises levels of histamine – the chemical that causes allergy symptoms – in the brain boosts our memory by around 10 per cent
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The allergy culprit histamine also boosts our memory
A drug that raises levels of histamine – the chemical that causes allergy symptoms – in the brain boosts our memory by around 10 per cent
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How extreme heat affects the body – and the best ways to cope
A short spell in a heat chamber at the University of Brighton showed Alec Luhn that his body is not adapted to high temperatures – but regular exposure can train the body to respond more effectively
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How extreme heat affects the body – and the best ways to cope
A short spell in a heat chamber at the University of Brighton showed Alec Luhn that his body is not adapted to high temperatures – but regular exposure can train the body to respond more effectively
Categories: Science
Peter Shor’s algorithm could break the internet – but he's not worried
Few people have invented an algorithm with the potential to spark a worldwide crisis, so why is quantum computing pioneer Peter Shor so unconcerned? Karmela Padavic-Callaghan spoke to him to find out
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Peter Shor’s algorithm could break the internet – but he's not worried
Few people have invented an algorithm with the potential to spark a worldwide crisis, so why is quantum computing pioneer Peter Shor so unconcerned? Karmela Padavic-Callaghan spoke to him to find out
Categories: Science
Does time come from the entire universe running computations?
Explaining the passage of time has been a gnarly problem in physics basically forever, but physicist and computer scientist Stephen Wolfram has a radical proposal for where it comes from. He discussed his ideas on time – and what they mean for free will – with reporter Leah Crane
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Does time come from the entire universe running computations?
Explaining the passage of time has been a gnarly problem in physics basically forever, but physicist and computer scientist Stephen Wolfram has a radical proposal for where it comes from. He discussed his ideas on time – and what they mean for free will – with reporter Leah Crane
Categories: Science
The strange metals forcing us to rethink how electricity really works
Some 40 years ago, physicists noticed certain metals were conducting electricity in a bizarre way no one could explain. New answers to how and why this happens are forcing us to question how electricity flows
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The strange metals forcing us to rethink how electricity really works
Some 40 years ago, physicists noticed certain metals were conducting electricity in a bizarre way no one could explain. New answers to how and why this happens are forcing us to question how electricity flows
Categories: Science
Salt batteries are about to shake up EVs and grid storage
Today, most rechargeable batteries are made from lithium ions, but sodium-ion alternatives could make battery tech much cheaper and offer other advantages
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Salt batteries are about to shake up EVs and grid storage
Today, most rechargeable batteries are made from lithium ions, but sodium-ion alternatives could make battery tech much cheaper and offer other advantages
Categories: Science
Chris Packham: 'I'd throw myself in front of a T. Rex to be consumed'
As Chris Packham gears up for his new TV show, Evolution, he tells Penny Sarchet why understanding the latest evolutionary science is so important if we are to truly appreciate the natural world - and how he would happily die at the hands of a Tyrannosaurus rex
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