Feedback is entertained by the commotion at the International Association for Cryptologic Research's recent elections, where results could not be decrypted after an "honest but unfortunate human mistake"

From Mickey 17 and M3gan 2.0 to a musical about the end of the world, this was an eclectic year for science-fiction films. Film columnist Simon Ings shares his two breakout hits

From animal rivals to Jane Goodall's last thoughts, enjoy 2025's best science documentaries, says our TV columnist Bethan Ackerley

Pet owners' increasing tendency to see their animals as children rather than dogs or cats can have dire consequences. Owners, and veterinarians, should be wary, warns Eddie Clutton

What were the year's top sci-fi shows? Andor and Severance are still up there, but our TV columnist Bethan Ackerley also has some unexpected tips to share

Feedback is entertained by the commotion at the International Association for Cryptologic Research's recent elections, where results could not be decrypted after an "honest but unfortunate human mistake"

We know that pets influence our microbiome, but scientists have now found that having a dog seems to change this ecosystem in a way that could boost our well-being

We know that pets influence our microbiome, but scientists have now found that having a dog seems to change this ecosystem in a way that could boost our well-being

The covid-19 pandemic opened the door to once-controversial human challenge trials. Now, volunteers are willingly catching norovirus and influenza to reveal how our immune systems really fight back

The covid-19 pandemic opened the door to once-controversial human challenge trials. Now, volunteers are willingly catching norovirus and influenza to reveal how our immune systems really fight back

More than half a million satellites are planned to launch by the end of the 2030s, and simulations suggest they will have a severe impact on space-based astronomy

More than half a million satellites are planned to launch by the end of the 2030s, and simulations suggest they will have a severe impact on space-based astronomy

A vaccine candidate induces antibodies that inhibit the ability of IgE antibodies to bind their receptor on granulocytes (Conde et al., this issue).

IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in mice.

PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia.

Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune microenvironment to alleviate the progression of MAFLD.

A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages and driving lung fibrosis.

Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.

Conventionally, the moon is thought to have formed during one big impact, but a three-impact model might make more sense