A CALR mutant–targeted CAR T cell therapy selectively depletes mutant CALR+ cancer stem cells in vivo and in fibrotic human bone marrow organoids.

Targeting the HIF-1α/PI3Kδ/IL-13 axis in chronic GVHD skin alleviates IL-13–driven hypoxia and subsequent fibrosis.

The integration of large-scale proteomic and genetic data identified 18 Alzheimer’s disease risk genes acting through regulation of blood proteins.

A microneedle stent enables intestinal anastomosis and localized drug delivery for postoperative adjuvant therapy in resectable intestinal diseases.

KS-PDX models demonstrate expansion of KSHV-infected endothelial cells with up-regulated angiogenic signaling pathways and CXCR4 expression.

Sci-fi fans can enjoy a new Red Dwarf novel – the first for 30 years – this month, as well as sci-fi horror from Paul Tremblay and a journey to Planet Happy with Riley August

Sci-fi fans can enjoy a new Red Dwarf novel – the first for 30 years – this month, as well as sci-fi horror from Paul Tremblay and a journey to Planet Happy with Riley August

Scientists worry that a surge of meltwater from Greenland could irreversibly collapse the Atlantic Meridional Overturning Circulation, but new modelling suggests the weakening of the current could be reversed if CO2 levels come back down

Scientists worry that a surge of meltwater from Greenland could irreversibly collapse the Atlantic Meridional Overturning Circulation, but new modelling suggests the weakening of the current could be reversed if CO2 levels come back down

The most comprehensive database ever compiled of how fast arachnids can run has shown how leg anatomy and evolutionary history influence spiders’ running speed

The most comprehensive database ever compiled of how fast arachnids can run has shown how leg anatomy and evolutionary history influence spiders’ running speed

The Vera C. Rubin Observatory in Chile is beginning its extraordinary survey of the southern sky, which will use the largest camera ever built to map the solar system, the galaxy and beyond

The Vera C. Rubin Observatory in Chile is beginning its extraordinary survey of the southern sky, which will use the largest camera ever built to map the solar system, the galaxy and beyond

Astronomers have recently started looking for black holes bigger than galaxies. Brian Lacki explains how these “stupendously large black holes” might be used by alien civilisations, and what makes them such an intriguing possibility

Astronomers have recently started looking for black holes bigger than galaxies. Brian Lacki explains how these “stupendously large black holes” might be used by alien civilisations, and what makes them such an intriguing possibility

Brain recordings from newborns reveal the first neural evidence that humans are born with an innate sense of numbers

Brain recordings from newborns reveal the first neural evidence that humans are born with an innate sense of numbers

When standard leukaemia treatments failed, 13-year-old Alyssa Tapley was told she had only weeks left – but then she was offered an experimental procedure

When standard leukaemia treatments failed, 13-year-old Alyssa Tapley was told she had only weeks left – but then she was offered an experimental procedure

The US government is trying to speed up the development of quantum computers so it can have one sooner