Science Translational Medicine weekly highlights
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Updated: 2 days 21 hours ago
Erratum for the Research Article “Guanosine diphosphate–mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer” | Science Translational Medicine
In the Research Article “Guanosine diphosphate–mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer” by Ding et al., duplication errors occurred between Fig. 3C and Fig. 5D and between fig. S3C and Fig. 2F. The blot for alpha-tubulin in Fig. 3C and colony images in fig. S3C have been corrected. The mislabeled concentrations in fig. S3C have been corrected. The online versions of Fig. 3C, the Supplementary Materials, and data files S1 and S2 have been updated. The corrections did not affect the conclusions of the paper.
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Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models | Science Translational Medicine
Neurotensin is an endogenous inhibitor of adverse cardiac remodeling.
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CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis | Science Translational Medicine
A CALR mutant–targeted CAR T cell therapy selectively depletes mutant CALR+ cancer stem cells in vivo and in fibrotic human bone marrow organoids.
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Hypoxia-driven T cell–macrophage–stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease | Science Translational Medicine
Targeting the HIF-1α/PI3Kδ/IL-13 axis in chronic GVHD skin alleviates IL-13–driven hypoxia and subsequent fibrosis.
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Alzheimer’s disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA | Science Translational Medicine
The integration of large-scale proteomic and genetic data identified 18 Alzheimer’s disease risk genes acting through regulation of blood proteins.
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Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases | Science Translational Medicine
A microneedle stent enables intestinal anastomosis and localized drug delivery for postoperative adjuvant therapy in resectable intestinal diseases.
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KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models | Science Translational Medicine
KS-PDX models demonstrate expansion of KSHV-infected endothelial cells with up-regulated angiogenic signaling pathways and CXCR4 expression.
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Erratum for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis” | Science Translational Medicine
HomeScience Translational MedicineVol. 18, No. 855Erratum for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis”Back To Vol. 18, No. 855 Full accessErrata Share on Erratum for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis”Science Translational Medicin…
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Kbtbd13 knockdown restores muscle function in a clinically relevant mouse model of nemaline myopathy type 6 | Science Translational Medicine
Mice carry the Dutch founder variant in Kbtbd13, phenocopy major human NEM6 pathology, and show reversal of muscle dysfunction with shRNA treatment.
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Human donor liver viability evaluation with polarization-sensitive optical coherence tomography | Science Translational Medicine
PS-OCT enables whole-organ, noninvasive viability assessment of human donor livers to support transplantation decision-making.
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Transferrin in combination with induction chemotherapy improves outcomes in mouse models of acute myeloid leukemia | Science Translational Medicine
Transferrin in combination with chemotherapy improves outcomes in preclinical AML.
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SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium | Science Translational Medicine
SPP1hi macrophages in synovial fibrin deposits promote tissue hyperplasia in the joints of individuals with rheumatoid arthritis.
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IgA is necessary and sufficient to prevent norovirus infection in mice | Science Translational Medicine
Mucosal IgA prevents norovirus infection in a murine model, which informs vaccine design and therapeutic strategies.
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AI-CURA, an automated LLM workflow for high-accuracy genetic variant classification | Science Translational Medicine
LLMs push the boundaries of fully automated variant classification, performing on par with human experts.
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Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation | Science Translational Medicine
Donor bone marrow combined with recipient regulatory T cells induces chimerism and immunomodulation without irradiation in kidney transplantation.
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Clinicogenomic analysis of EGFR-mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation | Science Translational Medicine
Integrated clinical, multiomic, and single-cell analyses reveal Rb inactivation as a driver of squamous transformation in EGFR-mutant lung cancer.
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The translational potential of drug-induced hypothermia in acute ischemic stroke | Science Translational Medicine
Hypothermia induced by chlorpromazine and promethazine is cerebroprotective in animal models and safe in patients with ischemic stroke.
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Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections | Science Translational Medicine
Incorporation of enzyme domains that initiate complement activation on target surfaces improves the utility of pathogen-targeting antibodies.
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Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17–driven endothelial activation | Science Translational Medicine
Plasma proteomics improves thrombosis prediction in cancer and uncovers a targetable CD200R1/IL-17–driven endothelial activation pathway in mice.
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Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae | Science Translational Medicine
The development, validation, and deployment of a deep learning model to identify antibiotic hit compounds for N. gonorrhoeae is described.
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