Science Translational Medicine weekly highlights
Science Translational Medicine: At the intersection of science, engineering and medicine.
Updated: 2 days 18 hours ago
Erratum for the Research Article “Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice” by J. Ramos da Silva et al. | Science Translational Medicine
In the Research Article “Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice” by J. Ramos da Silva et al., the image for the day 21 gDE7 U sa-mRNA-LNP group in Fig. 6B was erroneously duplicated in Fig. 6G. The day 21 gDE7 U sa-mRNA-LNP image in Fig. 6G has been updated with the correct image. The other data and conclusions in the manuscript were not affected.
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Brain-derived tau for monitoring brain injury in acute ischemic stroke | Science Translational Medicine
Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.
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An antibody cocktail targeting conserved, nonoverlapping epitopes prevents viral escape and confers protection against RSV in vivo | Science Translational Medicine
An antibody cocktail targeting conserved epitopes on the RSV A and B pre-F protein prevents viral escape and confers prophylactic protection in vivo.
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Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome | Science Translational Medicine
Soluble CD93 contributes to podocyte injury, and CD93 blockade emerges as a candidate therapeutic target in INS.
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Dual FAK and EPHA2 targeting by brigatinib tackles PARP inhibitor adaptive survival response in high-grade serous ovarian cancer | Science Translational Medicine
Brigatinib enhances PARPi response in HGSOC by disrupting adaptive survival of malignant cells by dual FAK and EPHA2 inhibition.
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Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma | Science Translational Medicine
FACT and BET inhibition in diffuse midline glioma drives tumor suppression and immune modulation, highlighting a dual therapeutic strategy.
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Erratum for Research Article "Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair" by K. Mylonas et al. | Science Translational Medicine
In the Research Article “Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair” by K. Mylonas et al., an inadvertent image duplication affected Fig. 3C. An immunofluorescent image of collagen I staining and quantification was presented correctly in Fig. 6I alongside a graph quantifying collagen I staining in young nonirradiated versus young irradiated kidneys, but it was accidentally duplicated and shown incorrectly accompanying a different graph of young versus aged kidney collagen I staining in Fig. 3C. Figure 3C has been replaced with a corrected image. The other data and the conclusions in the paper are not affected.
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When HIV pays the price: Fitness costs behind lenacapavir resistance | Science Translational Medicine
HIV can take several mutational pathways to become resistant to lenacapavir, each with distinct resistance and fitness profiles (Pennetzdorfer et al., this issue).
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Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions | Science Translational Medicine
Four months instead of the standard 6 months of drug therapy of less extensive tuberculosis disease had a higher risk of relapse.
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PET/CT imaging of tuberculosis lung lesions in marmosets treated with different drug regimens aligns with human clinical outcomes | Science Translational Medicine
Longitudinal PET/CT imaging data from the lungs of infected marmosets align with clinical treatment outcomes in patients with TB.
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Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects | Science Translational Medicine
Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and viral fitness impacts.
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Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice | Science Translational Medicine
CNS-targeted hematopoietic stem cell gene therapy shows efficacy in a mouse model of progranulin-related neurodegenerative disease.
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Extracellular BRICK1 drives heart repair after myocardial infarction in mice | Science Translational Medicine
The WAVE complex subunit BRICK1 functions as an angiogenic factor driving heart repair after myocardial infarction.
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HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine
HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.
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Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation | Science Translational Medicine
A comparison of dermatomyositis and lupus skin revealed that dermatomyositis is characterized by monocyte-mediated endothelial cell dysfunction.
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Reconnecting the vagus nerve to the heart through nerve conduit preserves cardiac function in a minipig model of right cardiac vagotomy | Science Translational Medicine
Partial repair of cardiac right vagus nerve using an implantable conduit after vagal resection limits cardiac tissue damage and dysfunction.
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Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts | Science Translational Medicine
ATR/PKMYT1 coinhibition induces synthetic lethality in Rb1-deficient breast cancers, supporting biomarker-guided therapy.
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FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection | Science Translational Medicine
Bacteria-targeted tuftsin–presenting nanoparticles stimulate the macrophage Fcγ receptor to improve antimicrobial defenses in sepsis.
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HDAC5 deacetylates cytosolic ACTN4 during skin reepithelialization and represents a therapeutic target for chronic wound healing | Science Translational Medicine
HDAC5 governs wound repair by deacetylating cytosolic ACTN4, and the selective activator G194-0712 improves chronic wound healing in mouse models.
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Targeting brain hubs of ictal fast ripple activity to reduce seizures in patients with drug-resistant epilepsy | Science Translational Medicine
Epileptic network analysis based on fast ripple interregional coincidence allows us to identify brain targets for neurostimulation treatment.
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