A swine and human study shows that treating multidrug-resistant Pseudomonas aeruginosa pneumonia with inhaled high-dose nitric oxide is safe.

Newborn screen metabolites encapsulate the risk for adverse outcomes of prematurity through a deep learning–based metabolic health index.

CAR T cells generated in vivo by T cell–targeted mRNA-LNP delivery eliminated scar-forming cells and ameliorated fibrosis in steatotic liver disease.

Integrated multiome analysis identifies loss of PPARG2 as a driver of liposarcoma dedifferentiation and GLP-1 signaling as a targetable program.

The histamine receptor H3 antagonist bavisant promotes neuroprotection and remyelination in cell and mouse models of multiple sclerosis.

In the Research Article “Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice” by J. Ramos da Silva et al., the image for the day 21 gDE7 U sa-mRNA-LNP group in Fig. 6B was erroneously duplicated in Fig. 6G. The day 21 gDE7 U sa-mRNA-LNP image in Fig. 6G has been updated with the correct image. The other data and conclusions in the manuscript were not affected.

Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.

An antibody cocktail targeting conserved epitopes on the RSV A and B pre-F protein prevents viral escape and confers prophylactic protection in vivo.

Soluble CD93 contributes to podocyte injury, and CD93 blockade emerges as a candidate therapeutic target in INS.

Brigatinib enhances PARPi response in HGSOC by disrupting adaptive survival of malignant cells by dual FAK and EPHA2 inhibition.

FACT and BET inhibition in diffuse midline glioma drives tumor suppression and immune modulation, highlighting a dual therapeutic strategy.

In the Research Article “Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair” by K. Mylonas et al., an inadvertent image duplication affected Fig. 3C. An immunofluorescent image of collagen I staining and quantification was presented correctly in Fig. 6I alongside a graph quantifying collagen I staining in young nonirradiated versus young irradiated kidneys, but it was accidentally duplicated and shown incorrectly accompanying a different graph of young versus aged kidney collagen I staining in Fig. 3C. Figure 3C has been replaced with a corrected image. The other data and the conclusions in the paper are not affected.

HIV can take several mutational pathways to become resistant to lenacapavir, each with distinct resistance and fitness profiles (Pennetzdorfer et al., this issue).

Four months instead of the standard 6 months of drug therapy of less extensive tuberculosis disease had a higher risk of relapse.

Longitudinal PET/CT imaging data from the lungs of infected marmosets align with clinical treatment outcomes in patients with TB.

Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and viral fitness impacts.

CNS-targeted hematopoietic stem cell gene therapy shows efficacy in a mouse model of progranulin-related neurodegenerative disease.

The WAVE complex subunit BRICK1 functions as an angiogenic factor driving heart repair after myocardial infarction.

HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.

A comparison of dermatomyositis and lupus skin revealed that dermatomyositis is characterized by monocyte-mediated endothelial cell dysfunction.