A cationic polymer promotes glycosaminoglycan assembly and secretion for treatment of preclinical cartilage injury and osteoarthritis.

A vaccine combining alum-anchored antigen and saponin adjuvant increases clonal expansion and clonal diversity of germinal center responses in mice.

Macrophage-drug conjugate displays high antitumor activity against glioblastoma by delivering cytotoxic payload and inducing immune activation.

OX40–heparan sulfate binding offers a potential strategy to improve CAR T cell tumor penetration.

LIGHT-HVEM signaling on ILC3s is crucial for tertiary lymphoid structure maturity and T cell–mediated antitumor immunity in CRC therapy.

The small-molecule ADAMTS-5 inhibitor GLPG1972 limits inflammation and fibrosis to reduce dystrophic muscle degeneration.

Microglia mediate the pruning of inhibitory synapses to disrupt gate control of a spinal circuit, resulting in pain hypersensitivity.

The molecular hallmarks of hydrocephalus provide a mechanistic framework to reclassify human disease subtypes and develop precision therapies.

Multiomic longitudinal data derived from whole blood identified four robust and longitudinally stable immunotypes in healthy adults.

Intra-articular injection of sc-rAAV2.5IL-1Ra is safe, stably increasing IL-1Ra concentration in joints, providing a potential osteoarthritis therapy.

IFN-γ–resistant CD28 CAR T cells exhibit potent antitumor activity because of reduced cell death, increased expansion, and long-term memory formation.

MTX exerts antitumor immune activity by inducing cGAMP generation in cancer cells and concurrently inhibiting its hydrolysis mediated by ENPP1.

A polymer prodrug strategy attacks drug-resistant Gram-negative bacteria at the site of infection.

NR2F2 modulates the ER cistrome, coregulator interactions, and chromatin accessibility to promote endocrine resistance in ER+ breast cancer.

The massive systemic release of cellular contents after hemorrhagic shock is gasdermin D dependent, an effect more prominent in females.

IRF1+ astrocytes exacerbate TBI pathology by promoting inflammation, BBB disruption, and CD8+ T cell infiltration.

Systemic cadherin-17–specific CAR T cell therapy is efficacious against colorectal cancer liver metastases in multiple preclinical models.

RORγt+FoxP3+ skin-resident regulatory T cells from the periphery contribute to the therapeutic benefit of allergen immunotherapy in atopic dermatitis.

The immunosuppressive capacity of regulatory T cell–derived extracellular vesicles is reduced in people with relapsing-remitting multiple sclerosis.

Hepatic inflammation-targeting pemafibrate reduces atherosclerosis in Ldlr−/− mice, supporting a role for inflammation in cardiovascular risk.