Broadly neutralizing antibodies targeting the HIV-1 envelope surface protein develop via a common maturation pathway in humans and macaques.

Rare de novo mutations disrupt CSF-brain development in patients and mouse models, linking ventriculomegaly to ASD and neurodevelopmental disorders.

Bacteriophage HER259 improves colitis severity mediated by Crohn’s disease Escherichia coli NRG857c and increases the efficacy of budesonide.

Inhibiting EGFR before treatment with temozolomide enhances its efficacy in experimental models of glioblastoma.

Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.

Competitive binding of cholesterol 25-hydroxylase with p62 inhibits autophagic degradation of α-synuclein.

In the Research Article “Guanosine diphosphate–mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer” by Ding et al., duplication errors occurred between Fig. 3C and Fig. 5D and between fig. S3C and Fig. 2F. The blot for alpha-tubulin in Fig. 3C and colony images in fig. S3C have been corrected. The mislabeled concentrations in fig. S3C have been corrected. The online versions of Fig. 3C, the Supplementary Materials, and data files S1 and S2 have been updated. The corrections did not affect the conclusions of the paper.

Neurotensin is an endogenous inhibitor of adverse cardiac remodeling.

A CALR mutant–targeted CAR T cell therapy selectively depletes mutant CALR+ cancer stem cells in vivo and in fibrotic human bone marrow organoids.

Targeting the HIF-1α/PI3Kδ/IL-13 axis in chronic GVHD skin alleviates IL-13–driven hypoxia and subsequent fibrosis.

The integration of large-scale proteomic and genetic data identified 18 Alzheimer’s disease risk genes acting through regulation of blood proteins.

A microneedle stent enables intestinal anastomosis and localized drug delivery for postoperative adjuvant therapy in resectable intestinal diseases.

KS-PDX models demonstrate expansion of KSHV-infected endothelial cells with up-regulated angiogenic signaling pathways and CXCR4 expression.

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Mice carry the Dutch founder variant in Kbtbd13, phenocopy major human NEM6 pathology, and show reversal of muscle dysfunction with shRNA treatment.

PS-OCT enables whole-organ, noninvasive viability assessment of human donor livers to support transplantation decision-making.

Transferrin in combination with chemotherapy improves outcomes in preclinical AML.

SPP1hi macrophages in synovial fibrin deposits promote tissue hyperplasia in the joints of individuals with rheumatoid arthritis.

Mucosal IgA prevents norovirus infection in a murine model, which informs vaccine design and therapeutic strategies.

LLMs push the boundaries of fully automated variant classification, performing on par with human experts.