Stemlike HIV-specific CD8+ T cells and limited viral epitope diversity are associated with durable HIV remission after treatment interruption.

ASO-mediated Hnrnph2 knockdown up-regulates Hnrnph1 and rescues multiple phenotypes in a mouse model of HNRNPH2-related neurodevelopmental disorder.

An RNA-delivered base editing strategy efficiently corrects the CFTR 1717-1G>A mutation that is otherwise unresponsive to current drug therapies.

Diabetes-driven TREM2-endothelial cross-talk impairs vascular repair in peripheral arterial disease.

The FDA-approved MEK1/2 inhibitor cobimetinib targets the YAP-TEAD complex to suppress hyperactivated YAP-induced tumor growth and tumorigenesis.

On 10 February 2021, Science Translational Medicine published the Research Article “Targeted immunotherapy for HER2-low breast cancer with 17p loss” by Y. Li et al. (1). A joint research misconduct investigation involving Indiana University, the Ohio State University, and the University of Maryland, College Park determined that falsification occurred during creation of fig. S9C. The institutions have requested that the Research Article be retracted, and Science Translational Medicine is, therefore, retracting the paper in full. Authors Kathy D. Miller and Bryan P. Schneider agreed with the Retraction; authors Yujing Li, Yifan Sun, Michael Kulke, Torsten Hechler, Kevin Van der Jeught, Xinna Zhang, and Xiongbin Lu disagreed with the Retraction; authors Bin He and Andreas Pahl did not respond; and authors Tianhan Dong and Milan Radovich could not be reached.

A brain-penetrant single-domain antibody degrader clears pathological tau and restores motor function in a tauopathy mouse model.

Therapeutic inhibition of ZNF281 prevents cardiotoxicity, enhances tumor regression, and prevents cancer metastasis.

Guinea pigs treated with ARN-75039 3 or 7 days after exposure to Lassa virus showed protection against lethal infection.

This study reveals two populations of cartilage stem cells in both human and mouse growth plates, reshaping our understanding of longitudinal growth.

On-demand expression of GLUT3 by CAR T cells boosted their antitumor efficacy against murine models of glioblastoma without causing systemic toxicity.

The GPR84 orphan receptor is a regulator of inflammation and a candidate therapeutic target in Buruli ulcer.

In the Research Article “Extracellular vesicle–mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice” by X. Pan et al., a competing interest was not disclosed in the initially published version. The following sentence was added the “Competing interests” section of the Acknowledgments: “M.H. has a financial interest in ExoDel, Inc., a company that options technology evaluated in this research and that could benefit from the results of the research.”

Keratin 16 suppresses type I interferon and innate immunity in the skin, offering insight into diseases such as pachyonychia congenita and psoriasis.

A human iPSC–derived tauopathy model endogenously recapitulates late-stage pathology and enables translational applications.

Activating macrophage phagocytosis with a WASp activator augments ibrutinib efficacy against primary and metastatic brain tumors.

An engineered protein receptor decoy protects mice from lethal infection caused by three antigenically distinct encephalitic alphaviruses.

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

Battery- and electronics-free theranostic contact lens tracks IOP and autonomously delivers drugs, enabling low-cost, personalized glaucoma care.

A simple intervention called E-MOTIVE can save a mother’s life by helping to manage bleeding after childbirth.