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Erratum for the Research Article “Phase separation–based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression” | Science Translational Medicine

The authors of the Research Article “Phase separation–based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression” by R. Yang et al. present one correction and two clarifications in the Supplementary Materials. In fig. S5, the values for 0.37 μM GNE-7883 in NCI-H2052 and NCI-H2373 cells were identical to those for 0.04 μM because of a copy-paste error. The authors retrieved the original data and corrected fig. S5 in the Supplementary Materials PDF and the data in data file S1. Some controls or samples were processed in the same experimental batch to minimize batch-to-batch variability and conserve samples. However, the data were presented in different figure panels for addressing distinct biological questions. To avoid misinterpretation, notations indicating concurrent samples have been added to data file S1 as follows: asterisk (*) for Fig. 4, N and O; asterisk (*) and hash tag (#) for Figs. 5A and 6A; and color marks for fig. S3A. In addition, the full-precision decimal values, raw measurements, and the calculation formula for fig. S21D are provided in data file S1 to avoid misinterpretation caused by rounding. The correction and clarifications do not affect the interpretation of the experiments or conclusions of the study.
Categories: Science

PTEN acts as a master mediator of nonhealing venous leg ulcers by suppressing immune response, angiogenesis, and lymphangiogenesis | Science Translational Medicine

PTEN drives the pathogenesis of nonhealing venous leg ulcers in humans, and its inhibition accelerates wound healing in mice.
Categories: Science

Murine autoantigen-specific type 1 regulatory T cells promote oligodendrogenesis through amphiregulin-EGFR signaling | Science Translational Medicine

Autoantigen-specific Tr1 cells repair autoimmune demyelination by delivering amphiregulin to the oligodendrocyte epidermal growth factor receptor.
Categories: Science

A small molecule reduces both parkinsonism and l-dopa–induced dyskinesia in animal models of Parkinson’s disease | Science Translational Medicine

Omics-guided discovery identified a protein kinase A modulator that reduced motor symptoms and l-dopa–induced dyskinesia in Parkinson’s disease models.
Categories: Science

Culturomics reveals Fusobacterium-Prevotella mutualism as a hallmark of nasopharyngeal tumor microbiota | Science Translational Medicine

A culturable nasopharyngeal bacterial catalog was built, which reveals mutualism between Fusobacterium and Prevotella that affects tumor therapy response.
Categories: Science

Long-term safety and efficacy of intracortical microstimulation in humans | Science Translational Medicine

Intracortical microstimulation in humans is safe and efficacious for up to 10 years.
Categories: Science

CD4+ T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis | Science Translational Medicine

CD4+ T cells in MS preferentially recognize EBV viral particles rather than latent antigens, and responses are reduced by B cell–targeting therapies.
Categories: Science

A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice | Science Translational Medicine

Mitochondrial uncoupling limits atheroprogression by improving insulin sensitivity, lowering triglycerides, and suppressing inflammasome activation.
Categories: Science

The Cheapest Music Streaming Service Is Free ... Kind Of

howstuffworks - Tue, 14/07/2026 - 17:21
If you're looking for the cheapest music streaming service, the answer depends on what you value most. Are you trying to save money? Do you want high-quality audio? Are you OK with ads? Is offline listening a must-have feature? Or are you simply searching for the largest music selection possible?

UN space database aimed at easing global tensions is mysteriously down

New Scientist - Space - Fri, 10/07/2026 - 18:11
A list of global space launches designed to calm cold war tensions and promote transparency has been missing from the UN's website for months
Categories: Science

UN space database aimed at easing global tensions is mysteriously down

New Scientist - Technology - Fri, 10/07/2026 - 18:11
A list of global space launches designed to calm cold war tensions and promote transparency has been missing from the UN's website for months
Categories: Science

Global warming already causing crop losses of over $20 billion a year

New Scientist - Space - Fri, 10/07/2026 - 18:00
Climate change is already having a big impact on crop yields, and the subsequent financial losses will continue to rise as the world keeps warming
Categories: Science

Global warming already causing crop losses of over $20 billion a year

New Scientist - Technology - Fri, 10/07/2026 - 18:00
Climate change is already having a big impact on crop yields, and the subsequent financial losses will continue to rise as the world keeps warming
Categories: Science

Mathematicians put AI to work on Fermat's last theorem

New Scientist - Space - Fri, 10/07/2026 - 15:00
At an event in London, mathematicians have made unexpectedly fast progress on formalising Fermat's last theorem using AI
Categories: Science

Mathematicians put AI to work on Fermat's last theorem

New Scientist - Technology - Fri, 10/07/2026 - 15:00
At an event in London, mathematicians have made unexpectedly fast progress on formalising Fermat's last theorem using AI
Categories: Science

The sneaky maths trick for solving problems without answering them

New Scientist - Space - Fri, 10/07/2026 - 12:00
How can you have a proof without proving anything? Mathematicians found a way and, in the process, came to blows over it – but 100 years on, this trick is a common part of modern maths, says columnist Jacob Aron
Categories: Science

The sneaky maths trick for solving problems without answering them

New Scientist - Technology - Fri, 10/07/2026 - 12:00
How can you have a proof without proving anything? Mathematicians found a way and, in the process, came to blows over it – but 100 years on, this trick is a common part of modern maths, says columnist Jacob Aron
Categories: Science

2026 eclipse: 5 citizen science projects you can contribute to

New Scientist - Space - Fri, 10/07/2026 - 09:00
During the August 2026 solar eclipse, scientists will be rushing to gather data on the sun, but even if you aren't a professional scientist, you can still help the research
Categories: Science

2026 eclipse: 5 citizen science projects you can contribute to

New Scientist - Technology - Fri, 10/07/2026 - 09:00
During the August 2026 solar eclipse, scientists will be rushing to gather data on the sun, but even if you aren't a professional scientist, you can still help the research
Categories: Science

Special relativity can warp chemical bonds – now we've seen it happen

New Scientist - Space - Thu, 09/07/2026 - 22:00
An experiment with a charged molecule of bismuth and carbon reveals how effects from Albert Einstein’s special relativity reshape the standard understanding of chemical bonds
Categories: Science

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