cfDNA fragmentomics of routine prenatal screening data identifies adverse pregnancy outcomes in immune-mediated disease (Stanley et al., this issue).

A first-in-human study demonstrates the feasibility and safety of base-edited anti-CD33 CAR T cells as a bridge to allogeneic transplantation in AML.

A single-cell transcriptomic atlas identified stromal and immune populations in renal tissue associated with lupus nephritis disease activity.

A configurable bioengineered multitissue platform with vascular circulation enables investigation of human breast cancer metastasis.

Urea transporter B–mediated urea influx impairs platelet function by inducing protein carbamylation, leading to bleeding in advanced CKD.

Cell-free DNA fragmentome analysis discriminates high-risk pregnant individuals who later developed adverse outcomes from those who did not.

MAPT splicing modulator compounds reduce 4R tau and rescue pathology in neurons derived from patients with tauopathy and mouse models.

The effectiveness of progranulin gene therapy in FTD models is improved by blocking the protein’s carboxyl terminus, which prevents sortilin binding.

Vaccination with high-avidity immunogens promotes germinal center seeding, B cell competitive fitness, and extrafollicular plasma cell responses.

Mosaic nanoparticles reveal that increasing epitope avidity promotes formation and persistence of memory B cell and long-lived plasma cell responses.

The VACIRiSS trial in adult sepsis survivors shows that PCV13 at ICU discharge did not perform better than placebo, with variable immunogenicity.

Targeting succinate-driven mitochondrial GPR91-CMPK2-cGAS-STING signaling in macrophages is a potential translatable strategy for RA therapy.

Combined siRNA-mediated silencing of MSH3 and HTT has synergistic therapeutic effects in a mouse model of Huntington’s disease.

Angiopoietin-1 RNA therapy slows the progression of WT1 glomerular disease in a preclinical mouse model.

Mutant p53 reactivation combined with DNA demethylation kills AML/MDS cells, showing efficacy in a pilot clinical trial.

Zika virus particles can assemble in the absence of the full-length premembrane structural protein.

In Fig. 3A of the Research Article “Follistatin gene delivery enhances muscle growth and strength in nonhuman primates” by Kota et al., the ELISpot data for the MCK promoter were erroneously duplicated as the data for the CMV promoter. The figure has been revised to illustrate the correct ELISpot data for the CMV promoter. This discrepancy did not affect the conclusions of the paper.

A genetic mouse model of IDH-mutant glioma responds to mutant IDH inhibitor (mIDHi) and shows that prior mIDHi treatment improves response to chemoradiation.

Fecal microbiome transplant up-regulates immune tolerance pathways in food allergy.

Dynamic immune and JAK-STAT–IFN signaling across time points after liver transplant parallels rejection outcomes.