Prime editing via RNA-LNP corrects multiple pathogenic ASS1 mutations and restores ureagenesis and survival in a mouse model of citrullinemia type I.

Somatosensory neurons prevent tendon degeneration by FGF1-mediated mesenchymal and macrophage regulation.

NeuroSense enables near real-time, multimodal monitoring of external ventricular drains in neurocritical care.

The urokinase receptor uPAR is highly expressed in recurrent glioblastoma and is targetable using anti-uPAR chimeric antigen receptor T cells.

Prime editing corrects a pathogenic human SCN1A mutation in mice, reducing seizure frequencies and improving survival in this GEFS+ model.

Through direct correction of a mutation causing Dravet syndrome, adenine base editing alleviates epileptic and premature mortality phenotypes in mice.

NKG2A checkpoint inhibition promotes lung fibrosis resolution.

In the experiment depicted in Fig. 5C of the Research Article “Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma,” by S. Manier et al., MYC (57 kDa) and MAF (48 kDa) were probed on the same membrane, and in the originally published MAF column, both bands were showing. The authors have since corrected the figure to clarify that the MAF band is accurately presented at 48 kDa. No data were affected, and the conclusions have not changed.

After publication of the Research Article “Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling” by K. Takada et al., the authors identified errors in fig. S7B, where two pairs of micrographs were inadvertently reused or misplaced. The sample 2 image for the SAH-BCL9MUT–treated group was a 180° rotation with partial duplication of sample 1 and has been replaced with the correct micrograph. For the vehicle-treated condition, the sample 1 and sample 2 images were inadvertently interchanged and have been corrected. Other data and the conclusions of the paper are not affected.

Longitudinal nasopharyngeal sampling reveals local influenza-specific B cell responses after intranasal, but not intramuscular, vaccination.

Genomic regulation of protein abundance differs substantially between human biofluids, affecting neurological disease–relevant target discovery.

Samples from patients with chronic hepatitis B and a mouse model revealed a central role for CD4+ T cells in hepatitis B virus clearance.

A single dose of an AAV vector encoding the CCR5-blocking antibody leronlimab drives suppression of viremia in SHIV-infected macaques.

Disrupting the ILM in vivo permits retinal integration of transplanted RGCs, enabling connectivity to light-sensing retinal circuits.

DPP6 regulates the cardiac INa-Ito balance, which is aberrantly influenced by clinically relevant DPP6 gene variants.

The original publication of the Focus “American medical education at a crossroads” by A. M. Feldman et al. omitted the disclosure that Marschall S. Runge was serving on the board of directors of Eli Lilly. The Acknowledgments section has been updated.

Reprogrammed TREM2+ macrophages drive nonresolving inflammation in peripheral artery disease associated with type 2 diabetes (Malhi et al., this issue).

Transcriptomics of peripheral blood from patients with breast cancer during therapy identifies changes in immunity linked to therapeutic response.

Stemlike HIV-specific CD8+ T cells and limited viral epitope diversity are associated with durable HIV remission after treatment interruption.

ASO-mediated Hnrnph2 knockdown up-regulates Hnrnph1 and rescues multiple phenotypes in a mouse model of HNRNPH2-related neurodevelopmental disorder.