A vaccine candidate induces antibodies that inhibit the ability of IgE antibodies to bind their receptor on granulocytes (Conde et al., this issue).

IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in mice.

PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia.

Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune microenvironment to alleviate the progression of MAFLD.

A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages and driving lung fibrosis.

Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.

Adjunctive ruxolitinib reduces inflammatory response after experimental malaria challenge and enhances immune memory responses to reinfection.

Lymphotoxin alpha represses acute myeloid leukemia by depleting TRAF2 and triggering cell death and myeloid differentiation.

Preclinical studies of adenine base editing approaches suggest safety and efficacy for patients with severe β-hemoglobinopathies.

Rapid gene expression changes during treatment of neonatal sepsis indicate reversibility of host immune response and enable prognostic approaches.

A multipathogen population serological study enabled inference of the antigenic landscape of cross-reacting arboviruses in a Bangladeshi population.

An early clinical study demonstrates feasibility of noninvasive 5-ALA sonodynamic treatment in nine patients with recurrent high-grade glioma.

Mouse and cell models suggest that GSK3β and the p35-CDK5-CRMP2 axis are potential therapeutic targets for promoting nerve repair in diabetes.

Epitope-diverse nanobody cocktails neutralize severe fever with thrombocytopenia syndrome virus and prevent lethal infection in animals.

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

Multiple myeloma cells with chromosome 1q amplification originate from CD24−FCRL5+ B cells and initiate malignant transformation.

Vaccination with antigen-displaying SyntEVs enhances GPC2 CAR T cell persistence and antitumor efficacy in models of neuroblastoma.

A modular metalloprotein in situ vaccine nanoplatform can establish antitumor immune response.

A nonabsorbable, intestinal TGR5-targeted conjugate was designed to improve glycemic control while reducing systemic toxicity in mice and pigs.