Science Translational Medicine weekly highlights

Subscribe to Science Translational Medicine weekly highlights feed Science Translational Medicine weekly highlights
Science Translational Medicine: At the intersection of science, engineering and medicine.
Updated: 1 week 6 days ago

Erratum for the Research Article “A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection” by L.-L. Wang et al. | Science Translational Medicine

Wed, 09/04/2025 - 16:01
Figure S8 of the Research Article “A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection” by L.-L. Wang et al. depicts P. aeruginosa–induced lung injuries in mice gavaged with either live or heat-killed E. lenta. After publication, the authors noted that two histological images had incorrectly been included in fig. S8B. These images have now been replaced with the correct ones. This correction does not affect the pathological scoring results or alter any conclusions of the study.
Categories: Science

Spatial genomics: Mapping the landscape of fibrosis | Science Translational Medicine

Wed, 09/04/2025 - 16:01
Spatial genomics unlocks insights into the pathobiology of multiorgan fibrosis across time and space.
Categories: Science

Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice | Science Translational Medicine

Wed, 09/04/2025 - 16:01
Collagen V regulates renal fibrosis and can be targeted with precision medicine approaches.
Categories: Science

Succinate-loaded tumor cell–derived microparticles reprogram tumor-associated macrophage metabolism | Science Translational Medicine

Wed, 09/04/2025 - 16:01
Engineered tumor cell–derived microparticles induce histone and enzyme succinylation in tumor-associated macrophages to promote an M1-like phenotype.
Categories: Science

Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay | Science Translational Medicine

Wed, 09/04/2025 - 16:01
A low complexity, portable lab-in-tube tuberculosis assay for resource-limited areas analyzes blood, saliva, and sputum with a handheld device.
Categories: Science

The mRNA export pathway licenses viral mimicry response and antitumor immunity by actively exporting nuclear retroelement transcripts | Science Translational Medicine

Wed, 09/04/2025 - 16:01
Tumor cells hijack the mRNA export pathway to obstruct nuclear export of retroelement transcripts for viral mimicry inhibition and immune evasion.
Categories: Science

The response to anti–PD-1 and anti–LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming | Science Translational Medicine

Wed, 09/04/2025 - 16:01
Treg instability drives anti–PD-1 + anti–LAG-3 treatment efficacy and is associated with therapeutic response in patients with metastatic melanoma.
Categories: Science

Path to a cure for debilitating pregnancy sickness | Science Translational Medicine

Wed, 02/04/2025 - 16:01
Identification of GDF15 as a cause of severe nausea and vomiting during pregnancy is opening new doors for treatment and prevention.
Categories: Science

Ebola virus vaccination elicits Ebola virus–specific immune responses without substantial cross-reactivity to other filoviruses | Science Translational Medicine

Wed, 02/04/2025 - 16:01
The Ad26/MVA Ebola virus vaccine elicited coordinated antibody and T cell responses that recognized Ebola virus but rarely other filoviruses.
Categories: Science

Human iPSC–derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models | Science Translational Medicine

Wed, 02/04/2025 - 16:01
Expanded human iPSC–derived nephron progenitor cells secrete renoprotective factors that have therapeutic potential for AKI and CKD.
Categories: Science

Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome | Science Translational Medicine

Wed, 02/04/2025 - 16:01
A gene therapy construct for Rett syndrome includes a self-regulating, miRNA-based feed-forward loop to prevent overexpression-related toxicity.
Categories: Science

Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis | Science Translational Medicine

Wed, 02/04/2025 - 16:01
The chemokine receptor 5 antagonist maraviroc attenuates EAE pathogenesis in mouse models of experimental autoimmune encephalomyelitis.
Categories: Science

Clinically compliant enrichment of human pluripotent stem cell–derived islets | Science Translational Medicine

Wed, 02/04/2025 - 16:01
Stem cell–derived islets can be enriched by density gradient separation.
Categories: Science

Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial | Science Translational Medicine

Wed, 02/04/2025 - 16:01
In a randomized, placebo-controlled clinical trial, mavoglurant reduced cocaine and alcohol use in 68 adults with chronic cocaine use disorder.
Categories: Science

Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine

Wed, 26/03/2025 - 15:01
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.
Categories: Science

CAR T cells based on fully human T cell receptor–mimetic antibodies exhibit potent antitumor activity in vivo | Science Translational Medicine

Wed, 26/03/2025 - 15:01
Development of fully human T cell receptor–mimetic antibodies enabled the generation of CAR T therapies against intracellular tumor-specific antigens.
Categories: Science

Variant screening of PYY3–36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity | Science Translational Medicine

Wed, 26/03/2025 - 15:01
A Y2 receptor–selective and long-acting PYY derivative improves weight loss and glucose metabolism in rodents in combination with a GLP-1 agonist.
Categories: Science

TRIM15 drives chondrocyte senescence and osteoarthritis progression | Science Translational Medicine

Wed, 26/03/2025 - 15:01
TRIM15 promotes chondrocyte senescence and osteoarthritis progression by mediating K48-linked ubiquitination and nuclear translocation of YAP.
Categories: Science

Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans | Science Translational Medicine

Wed, 26/03/2025 - 15:01
Comprehensive profiling of Ixodes scapularis antigens reveals that tick bites induce antivector immunity linked to acquired tick resistance.
Categories: Science

Identification and characterization of human retinal stem cells capable of retinal regeneration | Science Translational Medicine

Wed, 26/03/2025 - 15:01
Human neural retinal stem-like cells (hNRSCs) found in fetal retinas and organoids show promise for retinal regeneration and vision restoration.
Categories: Science

Pages