LTBP4 deficiency in CRC reprograms macrophages to facilitate metastasis.

Ambulatory 24-hour microdialysis reveals disrupted corticosteroid rhythms in primary aldosteronism.

Vaccine-induced antibodies and a predisposition to interferon responses contribute to the reactogenicity of mRNA vaccines.

FUS inactivation drove leptomeningeal metastatic outgrowth in non–small cell lung cancer by up-regulating the fatty acid transporter CD36.

Immune responses to urinary tract infections distinguished preterm birth in mice and were linked to birth outcomes in a human pregnancy cohort.

Acid ceramidase deficiency causes altered sphingolipid signaling and promotes disease phenotype(s) in a lysosomal storage disorder, CLN3 disease.

MLC1 antibodies are detected in a subset of patients with NMOSD-like disease and mediate astrocytopathy in rat encephalitis and mouse slices.

CWC22-regulated alternative splicing modulates efferocytic recycling of inosine in macrophages, thereby controlling fat mass.

cfDNA fragmentomics of routine prenatal screening data identifies adverse pregnancy outcomes in immune-mediated disease (Stanley et al., this issue).

A first-in-human study demonstrates the feasibility and safety of base-edited anti-CD33 CAR T cells as a bridge to allogeneic transplantation in AML.

A single-cell transcriptomic atlas identified stromal and immune populations in renal tissue associated with lupus nephritis disease activity.

A configurable bioengineered multitissue platform with vascular circulation enables investigation of human breast cancer metastasis.

Urea transporter B–mediated urea influx impairs platelet function by inducing protein carbamylation, leading to bleeding in advanced CKD.

Cell-free DNA fragmentome analysis discriminates high-risk pregnant individuals who later developed adverse outcomes from those who did not.

MAPT splicing modulator compounds reduce 4R tau and rescue pathology in neurons derived from patients with tauopathy and mouse models.

The effectiveness of progranulin gene therapy in FTD models is improved by blocking the protein’s carboxyl terminus, which prevents sortilin binding.

Vaccination with high-avidity immunogens promotes germinal center seeding, B cell competitive fitness, and extrafollicular plasma cell responses.

Mosaic nanoparticles reveal that increasing epitope avidity promotes formation and persistence of memory B cell and long-lived plasma cell responses.

The VACIRiSS trial in adult sepsis survivors shows that PCV13 at ICU discharge did not perform better than placebo, with variable immunogenicity.

Targeting succinate-driven mitochondrial GPR91-CMPK2-cGAS-STING signaling in macrophages is a potential translatable strategy for RA therapy.