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Erratum for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis” | Science Translational Medicine
HomeScience Translational MedicineVol. 18, No. 855Erratum for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis”Back To Vol. 18, No. 855 Full accessErrata Share on Erratum for the Research Article “In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis”Science Translational Medicin…
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Kbtbd13 knockdown restores muscle function in a clinically relevant mouse model of nemaline myopathy type 6 | Science Translational Medicine
Mice carry the Dutch founder variant in Kbtbd13, phenocopy major human NEM6 pathology, and show reversal of muscle dysfunction with shRNA treatment.
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Human donor liver viability evaluation with polarization-sensitive optical coherence tomography | Science Translational Medicine
PS-OCT enables whole-organ, noninvasive viability assessment of human donor livers to support transplantation decision-making.
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Transferrin in combination with induction chemotherapy improves outcomes in mouse models of acute myeloid leukemia | Science Translational Medicine
Transferrin in combination with chemotherapy improves outcomes in preclinical AML.
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SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium | Science Translational Medicine
SPP1hi macrophages in synovial fibrin deposits promote tissue hyperplasia in the joints of individuals with rheumatoid arthritis.
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IgA is necessary and sufficient to prevent norovirus infection in mice | Science Translational Medicine
Mucosal IgA prevents norovirus infection in a murine model, which informs vaccine design and therapeutic strategies.
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AI-CURA, an automated LLM workflow for high-accuracy genetic variant classification | Science Translational Medicine
LLMs push the boundaries of fully automated variant classification, performing on par with human experts.
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Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation | Science Translational Medicine
Donor bone marrow combined with recipient regulatory T cells induces chimerism and immunomodulation without irradiation in kidney transplantation.
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Clinicogenomic analysis of EGFR-mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation | Science Translational Medicine
Integrated clinical, multiomic, and single-cell analyses reveal Rb inactivation as a driver of squamous transformation in EGFR-mutant lung cancer.
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The translational potential of drug-induced hypothermia in acute ischemic stroke | Science Translational Medicine
Hypothermia induced by chlorpromazine and promethazine is cerebroprotective in animal models and safe in patients with ischemic stroke.
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Engineered antibodies bypass bacterial immune evasion to drive complement-mediated protection against lethal infections | Science Translational Medicine
Incorporation of enzyme domains that initiate complement activation on target surfaces improves the utility of pathogen-targeting antibodies.
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Plasma proteomics improves thrombosis prediction in patients with cancer and identifies targetable IL-17–driven endothelial activation | Science Translational Medicine
Plasma proteomics improves thrombosis prediction in cancer and uncovers a targetable CD200R1/IL-17–driven endothelial activation pathway in mice.
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Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae | Science Translational Medicine
The development, validation, and deployment of a deep learning model to identify antibiotic hit compounds for N. gonorrhoeae is described.
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A cocktail of human mAbs targeting the henipavirus fusion and receptor binding proteins provides cross-species neutralization | Science Translational Medicine
A cocktail of antibodies binding the fusion and receptor binding proteins of Nipah and Hendra viruses provides protection and resilience to resistance.
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Immune microenvironment and noncoding RNA shape early colorectal carcinogenesis in patients with premalignant lesions | Science Translational Medicine
Colorectal polyp risk is associated with adaptive local immune response and noncoding RNA expression.
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The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria | Science Translational Medicine
The fast-acting antimalarial drug MMV367 rapidly killed blood-stage parasites in healthy volunteers experimentally infected with Plasmodium falciparum.
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Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery | Science Translational Medicine
An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV+ head and neck cancer.
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SARS-CoV-2 variant booster vaccination and infection alter the breadth of the memory B cell repertoire | Science Translational Medicine
SARS-CoV-2 vaccination and infection differentially shift the memory B cell pool.
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IL-27–mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection | Science Translational Medicine
IL-27 potentiates severe fever with thrombocytopenia syndrome by disrupting hematopoiesis and amplifying inflammation.
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Hiding in plain sight | Science Translational Medicine
HIV-1–infected CD4+ T cells undergo lineage marker changes to become induced CD8+ T cells that harbor latent HIV-1 (Cai et al., this issue).
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