Science Translational Medicine weekly highlights


Science Translational Medicine: At the intersection of science, engineering and medicine.
Updated: 1 week 6 days ago
Erratum for the Research Article “A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection” by L.-L. Wang et al. | Science Translational Medicine
Figure S8 of the Research Article “A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection” by L.-L. Wang et al. depicts P. aeruginosa–induced lung injuries in mice gavaged with either live or heat-killed E. lenta. After publication, the authors noted that two histological images had incorrectly been included in fig. S8B. These images have now been replaced with the correct ones. This correction does not affect the pathological scoring results or alter any conclusions of the study.
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Spatial genomics: Mapping the landscape of fibrosis | Science Translational Medicine
Spatial genomics unlocks insights into the pathobiology of multiorgan fibrosis across time and space.
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Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice | Science Translational Medicine
Collagen V regulates renal fibrosis and can be targeted with precision medicine approaches.
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Succinate-loaded tumor cell–derived microparticles reprogram tumor-associated macrophage metabolism | Science Translational Medicine
Engineered tumor cell–derived microparticles induce histone and enzyme succinylation in tumor-associated macrophages to promote an M1-like phenotype.
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Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay | Science Translational Medicine
A low complexity, portable lab-in-tube tuberculosis assay for resource-limited areas analyzes blood, saliva, and sputum with a handheld device.
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The mRNA export pathway licenses viral mimicry response and antitumor immunity by actively exporting nuclear retroelement transcripts | Science Translational Medicine
Tumor cells hijack the mRNA export pathway to obstruct nuclear export of retroelement transcripts for viral mimicry inhibition and immune evasion.
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The response to anti–PD-1 and anti–LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming | Science Translational Medicine
Treg instability drives anti–PD-1 + anti–LAG-3 treatment efficacy and is associated with therapeutic response in patients with metastatic melanoma.
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Path to a cure for debilitating pregnancy sickness | Science Translational Medicine
Identification of GDF15 as a cause of severe nausea and vomiting during pregnancy is opening new doors for treatment and prevention.
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Ebola virus vaccination elicits Ebola virus–specific immune responses without substantial cross-reactivity to other filoviruses | Science Translational Medicine
The Ad26/MVA Ebola virus vaccine elicited coordinated antibody and T cell responses that recognized Ebola virus but rarely other filoviruses.
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Human iPSC–derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models | Science Translational Medicine
Expanded human iPSC–derived nephron progenitor cells secrete renoprotective factors that have therapeutic potential for AKI and CKD.
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Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome | Science Translational Medicine
A gene therapy construct for Rett syndrome includes a self-regulating, miRNA-based feed-forward loop to prevent overexpression-related toxicity.
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Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis | Science Translational Medicine
The chemokine receptor 5 antagonist maraviroc attenuates EAE pathogenesis in mouse models of experimental autoimmune encephalomyelitis.
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Clinically compliant enrichment of human pluripotent stem cell–derived islets | Science Translational Medicine
Stem cell–derived islets can be enriched by density gradient separation.
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Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial | Science Translational Medicine
In a randomized, placebo-controlled clinical trial, mavoglurant reduced cocaine and alcohol use in 68 adults with chronic cocaine use disorder.
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Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.
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CAR T cells based on fully human T cell receptor–mimetic antibodies exhibit potent antitumor activity in vivo | Science Translational Medicine
Development of fully human T cell receptor–mimetic antibodies enabled the generation of CAR T therapies against intracellular tumor-specific antigens.
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Variant screening of PYY3–36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity | Science Translational Medicine
A Y2 receptor–selective and long-acting PYY derivative improves weight loss and glucose metabolism in rodents in combination with a GLP-1 agonist.
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TRIM15 drives chondrocyte senescence and osteoarthritis progression | Science Translational Medicine
TRIM15 promotes chondrocyte senescence and osteoarthritis progression by mediating K48-linked ubiquitination and nuclear translocation of YAP.
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Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans | Science Translational Medicine
Comprehensive profiling of Ixodes scapularis antigens reveals that tick bites induce antivector immunity linked to acquired tick resistance.
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Identification and characterization of human retinal stem cells capable of retinal regeneration | Science Translational Medicine
Human neural retinal stem-like cells (hNRSCs) found in fetal retinas and organoids show promise for retinal regeneration and vision restoration.
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