Reprogrammed TREM2+ macrophages drive nonresolving inflammation in peripheral artery disease associated with type 2 diabetes (Malhi et al., this issue).

Transcriptomics of peripheral blood from patients with breast cancer during therapy identifies changes in immunity linked to therapeutic response.

Stemlike HIV-specific CD8+ T cells and limited viral epitope diversity are associated with durable HIV remission after treatment interruption.

ASO-mediated Hnrnph2 knockdown up-regulates Hnrnph1 and rescues multiple phenotypes in a mouse model of HNRNPH2-related neurodevelopmental disorder.

An RNA-delivered base editing strategy efficiently corrects the CFTR 1717-1G>A mutation that is otherwise unresponsive to current drug therapies.

Diabetes-driven TREM2-endothelial cross-talk impairs vascular repair in peripheral arterial disease.

The FDA-approved MEK1/2 inhibitor cobimetinib targets the YAP-TEAD complex to suppress hyperactivated YAP-induced tumor growth and tumorigenesis.

Simon Singh's exploration of mathematical proof – in particular Pierre de Fermat's last theorem – remains an absolute treasure, almost three decades after it was first published

Simon Singh's exploration of mathematical proof – in particular Pierre de Fermat's last theorem – remains an absolute treasure, almost three decades after it was first published

A final-stage trial has started of an mRNA vaccine against the bird flu strain infecting many animals – and occasionally people – worldwide

A final-stage trial has started of an mRNA vaccine against the bird flu strain infecting many animals – and occasionally people – worldwide

Most of Titan’s surface is oddly flat and smooth, and it may be because it is coated by as much as a metre of fluffy organic material that snowed down from the icy moon’s thick atmosphere

Most of Titan’s surface is oddly flat and smooth, and it may be because it is coated by as much as a metre of fluffy organic material that snowed down from the icy moon’s thick atmosphere

Some seemingly simple sequences of multiplication and addition grow so quickly that they question the very foundations of mathematics. In doing so, they demand a whole new level of logic

Some seemingly simple sequences of multiplication and addition grow so quickly that they question the very foundations of mathematics. In doing so, they demand a whole new level of logic

The ongoing conflict around the Strait of Hormuz has become a situation in game theory known as a war of attrition. The maths behind it can help explain what's going on, says Petros Sekeris

The ongoing conflict around the Strait of Hormuz has become a situation in game theory known as a war of attrition. The maths behind it can help explain what's going on, says Petros Sekeris

Experiment with nanodiamonds reveals that they are less rigid than other diamonds, adding to our understanding of how they could be used in new technologies

Experiment with nanodiamonds reveals that they are less rigid than other diamonds, adding to our understanding of how they could be used in new technologies

Filtering a protein that may cause sepsis out from the blood has shown promising signs for improving survival