A vaccine candidate induces antibodies that inhibit the ability of IgE antibodies to bind their receptor on granulocytes (Conde et al., this issue).

IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in mice.

PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia.

Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune microenvironment to alleviate the progression of MAFLD.

A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages and driving lung fibrosis.

Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.

Conventionally, the moon is thought to have formed during one big impact, but a three-impact model might make more sense

Conventionally, the moon is thought to have formed during one big impact, but a three-impact model might make more sense

Today, the deserts of the Arabian peninsula are inhospitable – but 100,000 years ago, the area was full of animals and ancient humans

Today, the deserts of the Arabian peninsula are inhospitable – but 100,000 years ago, the area was full of animals and ancient humans

The famous double-slit experiment brings into question the very nature of matter. Its cousin, the quantum eraser experiment, makes us question the very existence of time – and how much we can manipulate it

The famous double-slit experiment brings into question the very nature of matter. Its cousin, the quantum eraser experiment, makes us question the very existence of time – and how much we can manipulate it

Is there any science to viral relationship tests like the bird test, the orange peel theory and the moon phase test? Emily Impett, a professor of psychological and brain sciences at the University of Toronto, has the answers

Is there any science to viral relationship tests like the bird test, the orange peel theory and the moon phase test? Emily Impett, a professor of psychological and brain sciences at the University of Toronto, has the answers

We knew from prior analyses that a distant asteroid sampled in 2020 carried all but one of the molecules needed to kick-start life, and researchers have just found the missing ingredient: sugar

We knew from prior analyses that a distant asteroid sampled in 2020 carried all but one of the molecules needed to kick-start life, and researchers have just found the missing ingredient: sugar

Russia's only launch site capable of sending humans to orbit has suffered serious damage that may take two years to fix. Will NASA keep supporting the ISS without Russian involvement, or is this the end for the space station?

Russia's only launch site capable of sending humans to orbit has suffered serious damage that may take two years to fix. Will NASA keep supporting the ISS without Russian involvement, or is this the end for the space station?

Over the past 250 million years, periods when coral reef growth has peaked have coincided with big rises in sea temperatures