PTEN drives the pathogenesis of nonhealing venous leg ulcers in humans, and its inhibition accelerates wound healing in mice.

Autoantigen-specific Tr1 cells repair autoimmune demyelination by delivering amphiregulin to the oligodendrocyte epidermal growth factor receptor.

Omics-guided discovery identified a protein kinase A modulator that reduced motor symptoms and l-dopa–induced dyskinesia in Parkinson’s disease models.

A culturable nasopharyngeal bacterial catalog was built, which reveals mutualism between Fusobacterium and Prevotella that affects tumor therapy response.

Intracortical microstimulation in humans is safe and efficacious for up to 10 years.

CD4+ T cells in MS preferentially recognize EBV viral particles rather than latent antigens, and responses are reduced by B cell–targeting therapies.

Mitochondrial uncoupling limits atheroprogression by improving insulin sensitivity, lowering triglycerides, and suppressing inflammasome activation.

If you're looking for the cheapest music streaming service, the answer depends on what you value most. Are you trying to save money? Do you want high-quality audio? Are you OK with ads? Is offline listening a must-have feature? Or are you simply searching for the largest music selection possible?

A list of global space launches designed to calm cold war tensions and promote transparency has been missing from the UN's website for months

A list of global space launches designed to calm cold war tensions and promote transparency has been missing from the UN's website for months

Climate change is already having a big impact on crop yields, and the subsequent financial losses will continue to rise as the world keeps warming

Climate change is already having a big impact on crop yields, and the subsequent financial losses will continue to rise as the world keeps warming

At an event in London, mathematicians have made unexpectedly fast progress on formalising Fermat's last theorem using AI

At an event in London, mathematicians have made unexpectedly fast progress on formalising Fermat's last theorem using AI

How can you have a proof without proving anything? Mathematicians found a way and, in the process, came to blows over it – but 100 years on, this trick is a common part of modern maths, says columnist Jacob Aron

How can you have a proof without proving anything? Mathematicians found a way and, in the process, came to blows over it – but 100 years on, this trick is a common part of modern maths, says columnist Jacob Aron

During the August 2026 solar eclipse, scientists will be rushing to gather data on the sun, but even if you aren't a professional scientist, you can still help the research

During the August 2026 solar eclipse, scientists will be rushing to gather data on the sun, but even if you aren't a professional scientist, you can still help the research

An experiment with a charged molecule of bismuth and carbon reveals how effects from Albert Einstein’s special relativity reshape the standard understanding of chemical bonds

An experiment with a charged molecule of bismuth and carbon reveals how effects from Albert Einstein’s special relativity reshape the standard understanding of chemical bonds