SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

Cholesterol attenuates progesterone signaling through competitive binding of progesterone receptors.

GSNOR drives diabetic endothelial dysfunction by interacting with ERG.

In the Research Article “An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer” by M. Bahri et al., the dose of gemcitabine was incorrectly reported as 6.6 mg/kg in the captions of Figs. 1, 3, 5, and 6. All instances of the incorrect dose have been corrected to read 332 mg/kg. The incorrect value reflects the absolute amount of drug typically administered to a 20-g mouse rather than the correct allometrically scaled dose used in the study that was tailored to body weight. The conclusions and other data in the paper are not affected.

CAR T cells are found in the bone marrow (BM), where they maintain an activation state that results in inflammation that leads to BM hypoplasia.

When pancreatic cancer begins the metastatic cascade by spreading to veins, the cancer cells express genes associated with better patient outcomes.

Elevated afucosylation of IgG is associated with increased risk of productive DENV infection after Dengvaxia vaccination.

A selective USP5 inhibitor suppresses t(8;21) AML progression by selectively degrading AML1-ETO in PDX models.

Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.

Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.

Individuals at high risk for subsequent SARS-CoV-2 infections can be identified by analyzing antibody titers over time.

Cotton rats replicate human RSV infection at the genomic and single-cell level, underscoring their utility as a preclinical model for RSV infection.

Seizure-associated spreading depolarizations are potentially causing postictal symptoms in epilepsy.

Sex-specific differences in immune selection of HIV-1 reservoir cells during long-term antiretroviral therapy are driven by innate immunity.

Human intratumoral T cells treated with PD1-IL2v up-regulate chemotactic and effector molecules, leading to a potent antitumor response.

Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.

Humanlike broadly neutralizing B cell lineages to influenza hemagglutinin are elicited in cynomolgus macaques by an influenza vaccine candidate.

PXS-6302 reduces hydroxyproline and increases microvasculature in mature scars over baseline and placebo treatment, supporting phase 2 studies.

Restoring TIM4 in liver macrophages in MASH improves the efferocytosis of apoptotic hepatocytes, which dampens the progression to liver fibrosis.

A soft robotic device autonomously and rapidly guides intubation in models and cadavers and requires minimal skill and no visualization.