Multiomic analyses of longitudinally collected human glioblastoma samples reveal evolution of the tumor microenvironment in response to therapy.

LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

The FMRP-ASCC3 axis regulates collided ribosomes, and ASCC3 is reduced in fragile X syndrome, suggesting an alternative approach to treat the disease.

A biocompatible extracellular matrix hydrogel serves as a barrier to protect surgically injured tissue, limiting preclinical postoperative adhesions.

The relationship between genetic mutations and formation of specific amyloid fibril structures drives inheritance patterns of amyloid diseases.

Two doses of an inactivated trivalent vaccine protect mice and macaques against disease caused by encephalitic alphaviruses.

Deep phenotyping of blood and airway ILCs reveals heterogeneous, sex-specific, and dysregulated responses in severe asthma.

SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

Cholesterol attenuates progesterone signaling through competitive binding of progesterone receptors.

GSNOR drives diabetic endothelial dysfunction by interacting with ERG.

In the Research Article “An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer” by M. Bahri et al., the dose of gemcitabine was incorrectly reported as 6.6 mg/kg in the captions of Figs. 1, 3, 5, and 6. All instances of the incorrect dose have been corrected to read 332 mg/kg. The incorrect value reflects the absolute amount of drug typically administered to a 20-g mouse rather than the correct allometrically scaled dose used in the study that was tailored to body weight. The conclusions and other data in the paper are not affected.

CAR T cells are found in the bone marrow (BM), where they maintain an activation state that results in inflammation that leads to BM hypoplasia.

When pancreatic cancer begins the metastatic cascade by spreading to veins, the cancer cells express genes associated with better patient outcomes.

Elevated afucosylation of IgG is associated with increased risk of productive DENV infection after Dengvaxia vaccination.

A selective USP5 inhibitor suppresses t(8;21) AML progression by selectively degrading AML1-ETO in PDX models.

Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.

Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.

Individuals at high risk for subsequent SARS-CoV-2 infections can be identified by analyzing antibody titers over time.

Cotton rats replicate human RSV infection at the genomic and single-cell level, underscoring their utility as a preclinical model for RSV infection.