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Psychedelics may be no better than antidepressants for depression

New Scientist - Technology - Wed, 18/03/2026 - 17:00
Drugs like psilocybin that induce psychedelic effects have shown promise for treating depression. Now, a review of the evidence suggests that they are effective, but no more so than traditional antidepressants
Categories: Science

Route-planning AI cut climate-warming contrails on over 100 flights

New Scientist - Space - Wed, 18/03/2026 - 16:41
A weather-forecasting AI was used to recommend routes for American Airlines flights between the US and Europe to reduce the formation of contrails, which contribute to global warming
Categories: Science

Route-planning AI cut climate-warming contrails on over 100 flights

New Scientist - Technology - Wed, 18/03/2026 - 16:41
A weather-forecasting AI was used to recommend routes for American Airlines flights between the US and Europe to reduce the formation of contrails, which contribute to global warming
Categories: Science

Erratum for the Research Article “ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes” | Science Translational Medicine

The Research Article “ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes” by Y. Grobs et al. did not include the source of some samples when it was initially published. The second sentence of the “Human patient samples” section of the Materials and Methods has been updated to the following: “Samples were obtained from the CRCHUM (Centre de Recherche du Centre hospitalier de l'Université de Montréal) Respiratory Tissue and Cell Biobank with ethical approval number 08.063 from CRCHUM.” The Acknowledgments have been updated to note the contribution of the CRCHUM Respiratory Tissue and Cell Biobank, directed by E. Brochiero and coordinated by D. Adam, CRCHUM. The data and conclusions are not affected.
Categories: Science

Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies | Science Translational Medicine

A cohort of 60 mouse-intraductal patient-derived xenograft models of primary invasive breast cancer was developed to develop neoadjuvant treatments.
Categories: Science

Amyloid-β as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency | Science Translational Medicine

Blocking aberrant signaling of Aβ, GABAB1R/CaSR dimer, and Tau suppresses tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency.
Categories: Science

Lowering the HTT1a transcript as an effective therapy for Huntington’s disease in a knockin mouse model | Science Translational Medicine

Lowering the HTT1a transcript delays the onset of molecular and neuropathological phenotypes in a knockin mouse model of Huntington’s disease.
Categories: Science

Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington’s disease mice | Science Translational Medicine

Selective lowering of mHtt and Htt1a is superior to nonselective lowering of Htt in rescuing aggregate formation and transcriptional dysregulation.
Categories: Science

Disruption of the oligodendroglial miR-126a-3p–Pex5 axis inhibits remyelination in chronic demyelinating lesions | Science Translational Medicine

Dysregulation of the oligodendroglial miR-126a-3p–Pex5 axis represents a targetable barrier to remyelination in chronic multiple sclerosis lesions.
Categories: Science

Blood-brain barrier disruption, traumatic encephalopathy, and cognitive decline in retired athletes | Science Translational Medicine

Blood-brain barrier disruption is associated with cognitive decline and complement system activation in retired athletes.
Categories: Science

One Word Replaces Five Words

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
One single word can replace 5 distinct words in the following sentence:

"Sitting at the beach with soft sand, enjoying a premium wine, he continued reading a nice article that explained the small print in the county document about a traffic violation penalty."


Check Braingle.com for the answer.
Categories: Brain Teaser

SynoRhyme 2

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
In SynoRhyme, you are given a pair of words. Each of these words has a synonym, and these two synonyms rhyme. Your challenge is to figure out what these two words are.

For example, given the words "lure" and "excellent", you would need to determine the two answer words "bait" and "great", which are synonyms of "lure" and "excellent" respectively, and which rhyme.
The hint gives you the first letter of the first answer word for each word pair. So, for this example, the hint would be "b" (the first letter of "bait").

Good luck and have fun!

1. intelligent, flatulate
2. exist, bestow
3. cargo, forest
4. deliver, variety
5. competent, fixed


Check Braingle.com for the answer.
Categories: Brain Teaser

Rhyming Pairs 34

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
Think of two-word rhymes that are described by the clues:
Example: noisy gathering of many people Answer: loud crowd

1. zoo workers dedicated to the care of a long-necked creature
2. sweet available for purchase on the roadside
3. step taken in order to facilitate enjoyment
4. discussion in Port-au-Prince


Check Braingle.com for the answer.
Categories: Brain Teaser

Prevalent Primary

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
I'm present when there's no storm clouds to track
I'm an emergency code related to a heart attack
I'm that of a pet of a well-known lumberjack
I'm that of a sphere labelled "2" in a rack

What am I?


Check Braingle.com for the answer.
Categories: Brain Teaser

Common Syllable Connections

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
For each of the following, use the clues to determine a pair of words which share a common syllable.

For example, given: unbroken & skillful in dealing with difficult or delicate situations
the answer would be: intact & tactful.
These two words share the common syllable "tact". The common syllable does not need to have the same spelling in both words, just the same sound, according to American pronunciation.


1. ubiquitous man-made material used in the construction of many things & wonderful
2. strength & bad luck
3. held in a prison & atomic number 6 on the periodic table
4. shape & foreign visitor
5. as an alternative & unwavering


Check Braingle.com for the answer.
Categories: Brain Teaser

Make It Simple

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
What idiom is represented by the following?

QUADRAT_C EQUA_ION


Check Braingle.com for the answer.
Categories: Brain Teaser

Inconsistent Account

Newest Brain Teasers - Wed, 18/03/2026 - 08:00
What phrase is represented by the following?


Your assignment:

Change this:
Y
O
U
R

S
TORY

To this:
YOUR STORY


Check Braingle.com for the answer.
Categories: Brain Teaser

Social media is a defective product

New Scientist - Space - Tue, 17/03/2026 - 18:21
Two lawsuits are being brought against giant tech firms for the dangers their apps pose to young people. Columnist Annalee Newitz says the outcome of those cases could dramatically change social media for the better
Categories: Science

Social media is a defective product

New Scientist - Technology - Tue, 17/03/2026 - 18:21
Two lawsuits are being brought against giant tech firms for the dangers their apps pose to young people. Columnist Annalee Newitz says the outcome of those cases could dramatically change social media for the better
Categories: Science

A very serious guide to buying your own humanoid robot butler

New Scientist - Space - Tue, 17/03/2026 - 18:00
You can now buy a humanoid robot housekeeper for less than the price of a second-hand car. But before splashing out, there’s something you need to know
Categories: Science

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