Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus (Younis et al., this issue).

Incorporation of 5-methylcytidine alleviates RIG-I–dependent sensing of a self-amplifying RNA vaccine and reduces reactogenicity in vivo.

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

snoRNA Snord3-mediated epigenetic activation of ESM1 is a potential therapeutic target in rheumatoid arthritis.

Neuronavigation-guided focused ultrasound in conjunction with drug delivery can be successfully performed in children with progressive diffuse midline glioma without sedation.

Cationic nanogel–based nasal therapeutic vaccine induces cancer-specific immune responses and inhibits cancer development in cervical tissue.

High-throughput loading of sgRNA:Cas9 RNPs targeting Myo7aSh1 into extracellular vesicles prevents progressive hearing loss in an adult mouse model.

Lessons learned from Alzheimer’s disease biomarker history can advance diagnostics and disease staging for other central nervous system disorders.

TLR7 drives age-associated B cell formation in lupus through m6A demethylase FTO-mediated mitochondrial oxidation.

Plasmacytoid dendritic cells impair HIV-reactive CD8+ T cells in HIV-infected humanized mice and in PBMCs from people living with HIV.

MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.

Multiplexed imaging of aGVHD GI biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology.

Distinct temporal patterns of electrical stimulation of the sacral nerves selectively regulate colonic motility.

Triple combination therapy reverses endocrine resistance driven by DLL1high tumor cells, which recruit immunosuppressive PD-L1+ TAMs sustaining CSCs.

Itepekimab and dupilumab modulate both distinct and common inflammatory mediators in mouse models of airway inflammation and in humans with asthma.

Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.

Lymphotoxin-α release from B cells impairs neuronal activity in coculture models, which is reversible upon BTK inhibitor treatment.

Nearly isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight or obesity.

Viral and immune correlates of viral rebound dynamics post-ART were identified in an animal model of pediatric HIV infection.

PTPN2 deletion or inhibition boosts CAR T cell function and promotes the formation of stem cell memory CAR T cells for persistent solid tumor control.