An early clinical study demonstrates feasibility of noninvasive 5-ALA sonodynamic treatment in nine patients with recurrent high-grade glioma.

Mouse and cell models suggest that GSK3β and the p35-CDK5-CRMP2 axis are potential therapeutic targets for promoting nerve repair in diabetes.

Epitope-diverse nanobody cocktails neutralize severe fever with thrombocytopenia syndrome virus and prevent lethal infection in animals.

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

Multiple myeloma cells with chromosome 1q amplification originate from CD24−FCRL5+ B cells and initiate malignant transformation.

Vaccination with antigen-displaying SyntEVs enhances GPC2 CAR T cell persistence and antitumor efficacy in models of neuroblastoma.

A modular metalloprotein in situ vaccine nanoplatform can establish antitumor immune response.

A nonabsorbable, intestinal TGR5-targeted conjugate was designed to improve glycemic control while reducing systemic toxicity in mice and pigs.

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus (Younis et al., this issue).

Incorporation of 5-methylcytidine alleviates RIG-I–dependent sensing of a self-amplifying RNA vaccine and reduces reactogenicity in vivo.

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

snoRNA Snord3-mediated epigenetic activation of ESM1 is a potential therapeutic target in rheumatoid arthritis.

Neuronavigation-guided focused ultrasound in conjunction with drug delivery can be successfully performed in children with progressive diffuse midline glioma without sedation.

Cationic nanogel–based nasal therapeutic vaccine induces cancer-specific immune responses and inhibits cancer development in cervical tissue.

High-throughput loading of sgRNA:Cas9 RNPs targeting Myo7aSh1 into extracellular vesicles prevents progressive hearing loss in an adult mouse model.

Lessons learned from Alzheimer’s disease biomarker history can advance diagnostics and disease staging for other central nervous system disorders.

TLR7 drives age-associated B cell formation in lupus through m6A demethylase FTO-mediated mitochondrial oxidation.

Plasmacytoid dendritic cells impair HIV-reactive CD8+ T cells in HIV-infected humanized mice and in PBMCs from people living with HIV.

MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.

Multiplexed imaging of aGVHD GI biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology.