LRRC8A protein forms a complex with NMDA receptors through its C-terminal LRR domain, limiting their synaptic expression and pain hypersensitivity.

Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.

Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.

LRG1-driven microvascular dysfunction triggers early diabetic retinopathy, highlighting a potential therapeutic target.

HIVEP1 drives ODC1 expression and polyamine metabolism in liver TH17 cells to promote NAFLD-to-NASH progression.

Biselective LOX/HSP70 decoys remodel a tumor-supportive ECM, inhibit melanoma metastasis, and enhance CD8+ T cell immune response in mouse models.

Mucosal delivery of a rhesus adenovirus–vectored H5N1 influenza vaccine confers protection against lethal challenge in cynomolgus macaques.

Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.

Progression of crescentic glomerulonephritis is driven by intrarenal neutrophil differentiation and can be inhibited by low-dose glucocorticoids.

Deletion of the X-escapee gene Kdm6a in microglia reverses the disease-associated microglial translatome and has protective effects in female mice.

Multiomics on serial glioblastoma biopsies can enable differentiation of pseudoprogression from true tumor progression (see Ling et al.).

In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

Multiomic analyses of longitudinally collected human glioblastoma samples reveal evolution of the tumor microenvironment in response to therapy.

LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

The FMRP-ASCC3 axis regulates collided ribosomes, and ASCC3 is reduced in fragile X syndrome, suggesting an alternative approach to treat the disease.

A biocompatible extracellular matrix hydrogel serves as a barrier to protect surgically injured tissue, limiting preclinical postoperative adhesions.

The relationship between genetic mutations and formation of specific amyloid fibril structures drives inheritance patterns of amyloid diseases.

Two doses of an inactivated trivalent vaccine protect mice and macaques against disease caused by encephalitic alphaviruses.

Deep phenotyping of blood and airway ILCs reveals heterogeneous, sex-specific, and dysregulated responses in severe asthma.