Distinct temporal patterns of electrical stimulation of the sacral nerves selectively regulate colonic motility.

Triple combination therapy reverses endocrine resistance driven by DLL1high tumor cells, which recruit immunosuppressive PD-L1+ TAMs sustaining CSCs.

Itepekimab and dupilumab modulate both distinct and common inflammatory mediators in mouse models of airway inflammation and in humans with asthma.

Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.

Lymphotoxin-α release from B cells impairs neuronal activity in coculture models, which is reversible upon BTK inhibitor treatment.

Nearly isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight or obesity.

Viral and immune correlates of viral rebound dynamics post-ART were identified in an animal model of pediatric HIV infection.

PTPN2 deletion or inhibition boosts CAR T cell function and promotes the formation of stem cell memory CAR T cells for persistent solid tumor control.

LRRC8A protein forms a complex with NMDA receptors through its C-terminal LRR domain, limiting their synaptic expression and pain hypersensitivity.

Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.

Functionally stable regulatory T cells converted in vitro from pathogenic T cells can confer antigen-specific immunosuppression in pemphigus vulgaris.

LRG1-driven microvascular dysfunction triggers early diabetic retinopathy, highlighting a potential therapeutic target.

HIVEP1 drives ODC1 expression and polyamine metabolism in liver TH17 cells to promote NAFLD-to-NASH progression.

Biselective LOX/HSP70 decoys remodel a tumor-supportive ECM, inhibit melanoma metastasis, and enhance CD8+ T cell immune response in mouse models.

Mucosal delivery of a rhesus adenovirus–vectored H5N1 influenza vaccine confers protection against lethal challenge in cynomolgus macaques.

Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.

Progression of crescentic glomerulonephritis is driven by intrarenal neutrophil differentiation and can be inhibited by low-dose glucocorticoids.

Deletion of the X-escapee gene Kdm6a in microglia reverses the disease-associated microglial translatome and has protective effects in female mice.

Multiomics on serial glioblastoma biopsies can enable differentiation of pseudoprogression from true tumor progression (see Ling et al.).

In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.