Seizure-associated spreading depolarizations are potentially causing postictal symptoms in epilepsy.

Sex-specific differences in immune selection of HIV-1 reservoir cells during long-term antiretroviral therapy are driven by innate immunity.

Human intratumoral T cells treated with PD1-IL2v up-regulate chemotactic and effector molecules, leading to a potent antitumor response.

Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.

Humanlike broadly neutralizing B cell lineages to influenza hemagglutinin are elicited in cynomolgus macaques by an influenza vaccine candidate.

PXS-6302 reduces hydroxyproline and increases microvasculature in mature scars over baseline and placebo treatment, supporting phase 2 studies.

Restoring TIM4 in liver macrophages in MASH improves the efferocytosis of apoptotic hepatocytes, which dampens the progression to liver fibrosis.

A soft robotic device autonomously and rapidly guides intubation in models and cadavers and requires minimal skill and no visualization.

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

Type I interferon limits central nervous system autoimmunity by regulating microRNA-21 and pathogenic T helper 17 cell development.

Interferon-induced senescent CD8+ T cells mediate immunotherapy nonresponsiveness in early TNBC, which can be reversed by nicotinamide mononucleotide.

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

A longitudinal analysis after XBB.1.5 COVID-19 vaccination revealed durable neutralizing antibodies against ancestral and recent SARS-CoV-2 variants.

Inhibition of Slc38a2 in vascular endothelial cells enhances NO-mediated vasodilation and reduces blood pressure.

The allele-agnostic mutant-KRAS inhibitor panKRASi inhibits the growth of murine and human pancreatic cancer and promotes antitumor immunity.

oPool+ display enabled rapid antibody synthesis and screening of influenza hemagglutinin-specific antibodies.

An analysis of TCGA whole-genome sequencing samples yields a comprehensive resource for investigating the role of microbes in cancer.

Differences between cancer types, infectious disease, and potential prognostic markers are uncovered by studying microbes within cancer DNA.

Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with MS activity.

Targeting acid ceramidase enhances collagen degradation by hepatic stellate cells via PKCα and MMP-1, uncovering a pathway to reverse liver fibrosis.