Elevated afucosylation of IgG is associated with increased risk of productive DENV infection after Dengvaxia vaccination.

A selective USP5 inhibitor suppresses t(8;21) AML progression by selectively degrading AML1-ETO in PDX models.

Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.

Intravitreal delivery of an ELOVL2 product reduces age-related molecular changes in the retina and restores visual function.

Individuals at high risk for subsequent SARS-CoV-2 infections can be identified by analyzing antibody titers over time.

Cotton rats replicate human RSV infection at the genomic and single-cell level, underscoring their utility as a preclinical model for RSV infection.

Seizure-associated spreading depolarizations are potentially causing postictal symptoms in epilepsy.

Sex-specific differences in immune selection of HIV-1 reservoir cells during long-term antiretroviral therapy are driven by innate immunity.

Human intratumoral T cells treated with PD1-IL2v up-regulate chemotactic and effector molecules, leading to a potent antitumor response.

Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.

Humanlike broadly neutralizing B cell lineages to influenza hemagglutinin are elicited in cynomolgus macaques by an influenza vaccine candidate.

PXS-6302 reduces hydroxyproline and increases microvasculature in mature scars over baseline and placebo treatment, supporting phase 2 studies.

Restoring TIM4 in liver macrophages in MASH improves the efferocytosis of apoptotic hepatocytes, which dampens the progression to liver fibrosis.

A soft robotic device autonomously and rapidly guides intubation in models and cadavers and requires minimal skill and no visualization.

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

Type I interferon limits central nervous system autoimmunity by regulating microRNA-21 and pathogenic T helper 17 cell development.

Interferon-induced senescent CD8+ T cells mediate immunotherapy nonresponsiveness in early TNBC, which can be reversed by nicotinamide mononucleotide.

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

A longitudinal analysis after XBB.1.5 COVID-19 vaccination revealed durable neutralizing antibodies against ancestral and recent SARS-CoV-2 variants.

Inhibition of Slc38a2 in vascular endothelial cells enhances NO-mediated vasodilation and reduces blood pressure.