Nerve injury promotes IgG secretion from B cells, activating Fc gamma receptors in the dorsal root ganglia and spinal cord, leading to pain in mice.

Neutrophil extracellular traps are present in the urinary tract, help prevent ascending infection, and underlie positive urine dipsticks.

An extrathymic AIRE expression system uncovered a deep intronic AIRE variant that causes APECED and can be targeted with antisense oligonucleotides.

Preschool-age children mount a different adaptive immune response to SARS-CoV-2 than adults.

Radiation dose heterogeneity promotes systemic antitumor immunity through induction of diverse immune activation pathways.

ARGX-119 is a first-in-class MuSK agonist monoclonal antibody in clinical development for treatment of neuromuscular diseases.

Ultrasound perfusion metrics are correlated with acute spinal cord injury severity in rats and humans.

Antibody profiling and machine learning provide insight into the underlying pathophysiology of schistosome infection stages.

In the Research Article “Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70” by B. Brook et al., there was an error in Fig. 3D. The y axes were incorrectly labeled “% CD44+CD4+IFN-γ+ cells” and “% CD44+CD4+TNF+ cells.” The axes should be labeled “% CD44+CD8+IFN-γ+ cells” and “% CD44+CD8+TNF+ cells,” respectively. Figure 3D has now been corrected, and the main text has been updated to include that no difference was observed in the CD8+IFN-γ+ or CD8+TNF+ T cell responses. In the Fig. 2C caption, “BNT162b” has been corrected to “BNT162b2.” In the fig. S12 caption, the sentence “Mouse inguinal lymph nodes were evaluated by histology (A to O), and inguinal and popliteal lymph nodes were evaluated by (P) flow cytometry (Q) and weight” was corrected to “Mouse inguinal lymph nodes were evaluated by histology (A to M), and inguinal and popliteal lymph nodes were evaluated by (N) flow cytometry (O) and weight.” The online PDF and HTML (full text) and Supplementary Materials PDF have been updated. These corrections do not affect the interpretation of the data or the conclusions of the paper.

BATF deletion prevents epigenetic rewiring and enhances the antitumor activity of NK cells in AML.

HIF-2α regulates macrophage subtype–specific growth and function to enhance the development of NASH in obesity.

Reversal agents for rocuronium were identified from rocuronium-specific antibody repertoires.

A single-cell lung atlas integrated with clinical and blood signatures can predict disease trajectories in COVID-19 progression.

Reprogramming aged cells through targeted overexpression of Oct4, Sox2, and Klf4 leads to beneficial health effects in progeroid and aged mice.