Science Translational Medicine weekly highlights
Science Translational Medicine: At the intersection of science, engineering and medicine.
Updated: 1 day 18 hours ago
Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test | Science Translational Medicine
Neutrophil extracellular traps are present in the urinary tract, help prevent ascending infection, and underlie positive urine dipsticks.
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A deep intronic splice–altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion | Science Translational Medicine
An extrathymic AIRE expression system uncovered a deep intronic AIRE variant that causes APECED and can be targeted with antisense oligonucleotides.
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Preschool-age children maintain a distinct memory CD4+ T cell and memory B cell response after SARS-CoV-2 infection | Science Translational Medicine
Preschool-age children mount a different adaptive immune response to SARS-CoV-2 than adults.
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Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade | Science Translational Medicine
Radiation dose heterogeneity promotes systemic antitumor immunity through induction of diverse immune activation pathways.
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ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome | Science Translational Medicine
ARGX-119 is a first-in-class MuSK agonist monoclonal antibody in clinical development for treatment of neuromuscular diseases.
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Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans | Science Translational Medicine
Ultrasound perfusion metrics are correlated with acute spinal cord injury severity in rats and humans.
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Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis | Science Translational Medicine
Antibody profiling and machine learning provide insight into the underlying pathophysiology of schistosome infection stages.
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Erratum for the Research Article “Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70” by B. Brook et al. | Science Translational Medicine
In the Research Article “Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70” by B. Brook et al., there was an error in Fig. 3D. The y axes were incorrectly labeled “% CD44+CD4+IFN-γ+ cells” and “% CD44+CD4+TNF+ cells.” The axes should be labeled “% CD44+CD8+IFN-γ+ cells” and “% CD44+CD8+TNF+ cells,” respectively. Figure 3D has now been corrected, and the main text has been updated to include that no difference was observed in the CD8+IFN-γ+ or CD8+TNF+ T cell responses. In the Fig. 2C caption, “BNT162b” has been corrected to “BNT162b2.” In the fig. S12 caption, the sentence “Mouse inguinal lymph nodes were evaluated by histology (A to O), and inguinal and popliteal lymph nodes were evaluated by (P) flow cytometry (Q) and weight” was corrected to “Mouse inguinal lymph nodes were evaluated by histology (A to M), and inguinal and popliteal lymph nodes were evaluated by (N) flow cytometry (O) and weight.” The online PDF and HTML (full text) and Supplementary Materials PDF have been updated. These corrections do not affect the interpretation of the data or the conclusions of the paper.
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BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML | Science Translational Medicine
BATF deletion prevents epigenetic rewiring and enhances the antitumor activity of NK cells in AML.
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HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis | Science Translational Medicine
HIF-2α regulates macrophage subtype–specific growth and function to enhance the development of NASH in obesity.
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Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models | Science Translational Medicine
Reversal agents for rocuronium were identified from rocuronium-specific antibody repertoires.
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A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories | Science Translational Medicine
A single-cell lung atlas integrated with clinical and blood signatures can predict disease trajectories in COVID-19 progression.
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Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging | Science Translational Medicine
Reprogramming aged cells through targeted overexpression of Oct4, Sox2, and Klf4 leads to beneficial health effects in progeroid and aged mice.
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Erratum for the Research Article “MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells” by S. Perrin et al. | Science Translational Medicine
Because of a production error in the Research Article “MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells” by S. Perrin et al., the references cited in the Supplementary Materials were missing from the published article. These references have been added to the References and Notes list as numbers 57 to 68 in the PDF and the HTML, and the Supplementary Materials PDF has been updated with these reference numbers. The data and conclusions are not affected.
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Next-generation CAR T cell therapies for glioblastoma | Science Translational Medicine
Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).
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Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration | Science Translational Medicine
Induction of Rhoj in endothelial cells stimulates profibrotic vascular intussusception that hinders lung regeneration in mice.
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An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction | Science Translational Medicine
The PRDM1-S/SGK1 axis and AP-1/IRF epigenetic priming are drivers of Treg dysfunction in multiple sclerosis and other autoimmune diseases.
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Activation and antitumor immunity of CD8+ T cells are supported by the glucose transporter GLUT10 and disrupted by lactic acid | Science Translational Medicine
GLUT10 enhances glucose uptake in CD8+ T cells to improve antitumor function.
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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer | Science Translational Medicine
Combining MEK/CDK4/6 inhibitors with nanoparticle delivery of STING/TLR4 agonists leads to T cell–mediated control of pancreatic tumors in mice.
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Repeated Omicron exposures redirect SARS-CoV-2–specific memory B cell evolution toward the latest variants | Science Translational Medicine
Immunological imprinting to the SARS-CoV-2 spike protein by memory B cells is redirected toward Omicron sublineages after repeated BA.5 exposures.
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