Potent lysyl-tRNA synthetase inhibitors advance our understanding of desirable properties for achieving efficacy in cryptosporidiosis animal models.

Human FOXP3 promoter–driven OX40L–CAR-Tregs potently suppress alloreactivity and control graft-versus-host disease.

Nuclide and optical probes targeting TROP2 support the identification of margins during breast-conserving surgery in patients with breast cancer.

Versatile PAMless CRISPR base editors enable efficient and precise therapeutic correction of CGD mutations in hematopoietic stem and progenitor cells.

MTNR1A loss-of-function variant rs374152717 impairs bone turnover and provides evidence of a genetic etiology of idiopathic osteoporosis.

After nerve injury, follistatin is up-regulated and interacts with IGF1R to activate Nav1.7 in nociceptive neurons, leading to neuropathic pain.

Increased airway NK cells, altered circulating NK cell immunophenotype, and cytotoxic dysfunction are associated with severe pediatric RSV infection.

Reversible attention deficits after early adversity are mediated by sleep across species.

Multispecific antibodies to SARS-CoV-2 increase pseudovirus neutralization breadth and potency and inhibit immune escape in vitro.

Mitochondrial creatine kinase 2 is decreased in type 2 diabetes, which impairs skeletal muscle mitochondrial function.

Unraveling the cancer-stroma interactome in myelofibrosis reveals galectin-1 as an actionable target.

Temozolomide resistance in MGMT-methylated glioblastoma is mediated by a CHK1/DDX46 axis that can be blocked by the addition of a CHK1 inhibitor.

A microbiome-directed food targeting specific gut bacterial taxa promotes growth in Bangladeshi children recovering from severe acute malnutrition.

LRRK2 kinase activity drives reactive oxygen species production in Parkinson’s disease through regulation of NADPH oxidase 2.

A tumor-specific peptide translated from a MYC-associated uORF binds to tropomyosin receptor kinase B and promotes glioblastoma growth.

Glucocorticoid receptor activation in renal tubular epithelial cells amplifies DNA damage, impairs mitochondrial bioenergetics, and worsens injury.

Scientific and clinical advances have expanded our ability to understand, prevent, and treat diverse forms of skin fibrosis.

Inhibition of CYP1B1 in HSCs and trehalose/lactotrehalose dosing show preclinical antifibrotic effects in male animals.

Reducing excitatory neuron swelling improved locomotor functional recovery after spinal cord injury in mice.

Spermidine is essential for the function of leukemia stem and progenitor cells through the regulation of KAT7 expression.